TY - JOUR
T1 - Facile biocatalytic synthesis of a macrocyclic lactone in sub- and supercritical solvents
AU - Karmee, Sanjib Kumar
AU - Niemeijer, Bernd
AU - Casiraghi, Laura
AU - Mlambo, Benhilda
AU - Lapkin, Alexei
AU - Greiner, Lasse
PY - 2014
Y1 - 2014
N2 - High yield and selectivity in the intramolecular synthesis of the macrocyclic lactone oxacyclohexadecan-2-one were achieved via a straightforward biocatalytic synthesis utilising non-conventional solvents: supercritical carbon dioxide (scCO2), ethane, fluoroform and 1,1,1,2-tetrafluoroethane. Batch and continuous syntheses were demonstrated with a higher yield attained in a continuous synthesis using in-situ product extraction by scCO2. A remarkably high yield was obtained in 1,1,1,2-tetrafluoroethane at batch conditions.
AB - High yield and selectivity in the intramolecular synthesis of the macrocyclic lactone oxacyclohexadecan-2-one were achieved via a straightforward biocatalytic synthesis utilising non-conventional solvents: supercritical carbon dioxide (scCO2), ethane, fluoroform and 1,1,1,2-tetrafluoroethane. Batch and continuous syntheses were demonstrated with a higher yield attained in a continuous synthesis using in-situ product extraction by scCO2. A remarkably high yield was obtained in 1,1,1,2-tetrafluoroethane at batch conditions.
KW - Hydrofluorocarbons
KW - Lipase
KW - Macrolide
KW - Supercritical solvents
UR - http://www.scopus.com/inward/record.url?scp=84896976440&partnerID=8YFLogxK
UR - http://dx.doi.org/10.3109/10242422.2014.893579
U2 - 10.3109/10242422.2014.893579
DO - 10.3109/10242422.2014.893579
M3 - Article
AN - SCOPUS:84896976440
SN - 1024-2422
VL - 32
SP - 125
EP - 131
JO - Biocatalysis and Biotransformation
JF - Biocatalysis and Biotransformation
IS - 2
ER -