Facile biocatalytic synthesis of a macrocyclic lactone in sub- and supercritical solvents

Sanjib Kumar Karmee, Bernd Niemeijer, Laura Casiraghi, Benhilda Mlambo, Alexei Lapkin, Lasse Greiner

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

High yield and selectivity in the intramolecular synthesis of the macrocyclic lactone oxacyclohexadecan-2-one were achieved via a straightforward biocatalytic synthesis utilising non-conventional solvents: supercritical carbon dioxide (scCO2), ethane, fluoroform and 1,1,1,2-tetrafluoroethane. Batch and continuous syntheses were demonstrated with a higher yield attained in a continuous synthesis using in-situ product extraction by scCO2. A remarkably high yield was obtained in 1,1,1,2-tetrafluoroethane at batch conditions.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalBiocatalysis and Biotransformation
Volume32
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Hydrofluorocarbons
  • Lipase
  • Macrolide
  • Supercritical solvents

ASJC Scopus subject areas

  • Catalysis
  • Biotechnology
  • Biochemistry

Fingerprint Dive into the research topics of 'Facile biocatalytic synthesis of a macrocyclic lactone in sub- and supercritical solvents'. Together they form a unique fingerprint.

  • Cite this