This study investigates a new family of self-doped sulfonated polyaniline (S-PANI) membranes addressing key challenges of PANI membranes including acid leaching, fouling and solvent stability issues. The pure S-PANI membranes were prepared via phase inversion from a solution of doped S-PANI, NMP, 4-MP and THF and were further cross-linked via thermal treatment and chemical treatment using DCX, GA and TCL. The produced membranes were compared to pure PANI membrane to determine performance, antifouling and hydrophilicity. Filtration experiments carried out with pure water showed that pure S-PANI membrane has properties comparable to those of current UF PANI membranes. The Polyethylene glycol (PEG) mixture filtration showed that rejection performance of cross-linked membranes were higher, about 2.3 times, than pure PANI and S-PANI membranes with S-PANI GA showing a MWCO of 1800 Da. Furthermore, chemically cross-linked membranes showed enhanced in-ﬁltration stability in DMF and reusability. Fouling performance of prepared membranes, using BSA, showed a significant improvement of flux recovery for S-PANI and S-PANI GA after three cleaning-fouling cycles, with the membranes regaining 87 % and 83% of their original flux, respectively. Overall, this study provides a simple method to produce low fouling and long-term solvent resistant membranes for the application in the UF/tight UF range.