Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

J B Chaudhuri; M G Davidson; M J Ellis; M D Jones; X J Wu

doi:10.1002/masy.200851206

Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

J B Chaudhuri, M G Davidson, M J Ellis, M D Jones, X J Wu

Research output: Contribution to journal › Article › peer-review

33 Citations (SciVal)

Abstract

Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.

Original language	English
Pages (from-to)	52-57
Number of pages	6
Journal	Macromolecular Symposia
Volume	272
Issue number	1
DOIs	https://doi.org/10.1002/masy.200851206
Publication status	Published - 2008
Event	International Conference on (Bio)degradable Polymers from Renewable Resources - Vienna, Austria Duration: 1 Jan 2008 → …

Bibliographical note

International Conference on (Bio)degradable Polymers from Renewable Resources Vienna, AUSTRIA, NOV 18-21, 2007

Keywords

tissue engineering
thin film
biodegradable
scaffold
honeycomb

Access to Document

10.1002/masy.200851206

Cite this

@article{3e1b97b34b114e169765a1fd16e6c64c,

title = "Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture",

abstract = "Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.",

keywords = "tissue engineering, thin film, biodegradable, scaffold, honeycomb",

author = "Chaudhuri, \{J B\} and Davidson, \{M G\} and Ellis, \{M J\} and Jones, \{M D\} and Wu, \{X J\}",

note = "International Conference on (Bio)degradable Polymers from Renewable Resources Vienna, AUSTRIA, NOV 18-21, 2007; International Conference on (Bio)degradable Polymers from Renewable Resources ; Conference date: 01-01-2008",

year = "2008",

doi = "10.1002/masy.200851206",

language = "English",

volume = "272",

pages = "52--57",

journal = "Macromolecular Symposia",

issn = "1022-1360",

publisher = "Wiley-VCH Verlag",

number = "1",

}

TY - JOUR

T1 - Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

AU - Chaudhuri, J B

AU - Davidson, M G

AU - Ellis, M J

AU - Jones, M D

AU - Wu, X J

N1 - International Conference on (Bio)degradable Polymers from Renewable Resources Vienna, AUSTRIA, NOV 18-21, 2007

PY - 2008

Y1 - 2008

N2 - Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.

AB - Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.

KW - tissue engineering

KW - thin film

KW - biodegradable

KW - scaffold

KW - honeycomb

UR - https://www.scopus.com/pages/publications/55849120787

UR - http://dx.doi.org/10.1002/masy.200851206

U2 - 10.1002/masy.200851206

DO - 10.1002/masy.200851206

M3 - Article

SN - 1022-1360

VL - 272

SP - 52

EP - 57

JO - Macromolecular Symposia

JF - Macromolecular Symposia

IS - 1

T2 - International Conference on (Bio)degradable Polymers from Renewable Resources

Y2 - 1 January 2008

ER -

Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this