Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

J B Chaudhuri, M G Davidson, M J Ellis, M D Jones, X J Wu

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.
Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalMacromolecular Symposia
Volume272
Issue number1
DOIs
Publication statusPublished - 2008
EventInternational Conference on (Bio)degradable Polymers from Renewable Resources - Vienna, Austria
Duration: 1 Jan 2008 → …

Keywords

  • tissue engineering
  • thin film
  • biodegradable
  • scaffold
  • honeycomb

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