Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method

Andrea Macchetta, Irene G Turner, Christopher R Bowen

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

A room temperature camphene-based freeze-casting method was used to fabricate hydroxyapatite/tricalcium phosphate (HA/TCP) ceramic scaffolds. By varying the solid loading of the mixture and the freezing temperature, a range of structures with different pore sizes and strength characteristics were achieved. The macropore size of the HA/TCP bioceramics was in the range of 100-200 mu m, 40-80 mu m and less than 40 mu m at solid loadings of 10, 20 and 30 vol.%, respectively. The initial level of solid loading played a primary role in the resulting porosity of the scaffolds. The porosity decreased from 72.5 to 31.4 vol.% when the solid loading was increased from 10 to 30 vol.%. This resulted in an increase in the compressive strength from 2.3 to 36.4 MPa. The temperature gradient, rather than the percentage porosity, influenced the pore size distribution. The compressive strength increased from 1.95 to 2.98 MPa when samples were prepared at 4 degrees C as opposed to 30 degrees C. The results indicated that it was possible to manufacture porous HA/TCP bioceramics, with compressive strengths comparable to cancellous bone, using the freeze-casting manufacturing technique, which could be of significant clinical interest.
Original languageEnglish
Pages (from-to)1319-1327
Number of pages9
JournalActa Biomaterialia
Volume5
Issue number4
Early online date6 Dec 2008
DOIs
Publication statusPublished - May 2009

Fingerprint

Camphene
Compressive Strength
Porosity
Durapatite
Hydroxyapatite
Scaffolds
Casting
Phosphates
Compressive strength
Bioceramics
Fabrication
Temperature
Pore size
Freezing
Thermal gradients
Bone
camphene
tricalcium phosphate

Keywords

  • Hydroxyapatite
  • Bioceramics
  • Porous
  • Freeze-casting

Cite this

Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. / Macchetta, Andrea; Turner, Irene G; Bowen, Christopher R.

In: Acta Biomaterialia, Vol. 5, No. 4, 05.2009, p. 1319-1327.

Research output: Contribution to journalArticle

@article{5b53b8806db244ada986d96ce8261c01,
title = "Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method",
abstract = "A room temperature camphene-based freeze-casting method was used to fabricate hydroxyapatite/tricalcium phosphate (HA/TCP) ceramic scaffolds. By varying the solid loading of the mixture and the freezing temperature, a range of structures with different pore sizes and strength characteristics were achieved. The macropore size of the HA/TCP bioceramics was in the range of 100-200 mu m, 40-80 mu m and less than 40 mu m at solid loadings of 10, 20 and 30 vol.{\%}, respectively. The initial level of solid loading played a primary role in the resulting porosity of the scaffolds. The porosity decreased from 72.5 to 31.4 vol.{\%} when the solid loading was increased from 10 to 30 vol.{\%}. This resulted in an increase in the compressive strength from 2.3 to 36.4 MPa. The temperature gradient, rather than the percentage porosity, influenced the pore size distribution. The compressive strength increased from 1.95 to 2.98 MPa when samples were prepared at 4 degrees C as opposed to 30 degrees C. The results indicated that it was possible to manufacture porous HA/TCP bioceramics, with compressive strengths comparable to cancellous bone, using the freeze-casting manufacturing technique, which could be of significant clinical interest.",
keywords = "Hydroxyapatite, Bioceramics, Porous, Freeze-casting",
author = "Andrea Macchetta and Turner, {Irene G} and Bowen, {Christopher R}",
year = "2009",
month = "5",
doi = "10.1016/j.actbio.2008.11.009",
language = "English",
volume = "5",
pages = "1319--1327",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method

AU - Macchetta, Andrea

AU - Turner, Irene G

AU - Bowen, Christopher R

PY - 2009/5

Y1 - 2009/5

N2 - A room temperature camphene-based freeze-casting method was used to fabricate hydroxyapatite/tricalcium phosphate (HA/TCP) ceramic scaffolds. By varying the solid loading of the mixture and the freezing temperature, a range of structures with different pore sizes and strength characteristics were achieved. The macropore size of the HA/TCP bioceramics was in the range of 100-200 mu m, 40-80 mu m and less than 40 mu m at solid loadings of 10, 20 and 30 vol.%, respectively. The initial level of solid loading played a primary role in the resulting porosity of the scaffolds. The porosity decreased from 72.5 to 31.4 vol.% when the solid loading was increased from 10 to 30 vol.%. This resulted in an increase in the compressive strength from 2.3 to 36.4 MPa. The temperature gradient, rather than the percentage porosity, influenced the pore size distribution. The compressive strength increased from 1.95 to 2.98 MPa when samples were prepared at 4 degrees C as opposed to 30 degrees C. The results indicated that it was possible to manufacture porous HA/TCP bioceramics, with compressive strengths comparable to cancellous bone, using the freeze-casting manufacturing technique, which could be of significant clinical interest.

AB - A room temperature camphene-based freeze-casting method was used to fabricate hydroxyapatite/tricalcium phosphate (HA/TCP) ceramic scaffolds. By varying the solid loading of the mixture and the freezing temperature, a range of structures with different pore sizes and strength characteristics were achieved. The macropore size of the HA/TCP bioceramics was in the range of 100-200 mu m, 40-80 mu m and less than 40 mu m at solid loadings of 10, 20 and 30 vol.%, respectively. The initial level of solid loading played a primary role in the resulting porosity of the scaffolds. The porosity decreased from 72.5 to 31.4 vol.% when the solid loading was increased from 10 to 30 vol.%. This resulted in an increase in the compressive strength from 2.3 to 36.4 MPa. The temperature gradient, rather than the percentage porosity, influenced the pore size distribution. The compressive strength increased from 1.95 to 2.98 MPa when samples were prepared at 4 degrees C as opposed to 30 degrees C. The results indicated that it was possible to manufacture porous HA/TCP bioceramics, with compressive strengths comparable to cancellous bone, using the freeze-casting manufacturing technique, which could be of significant clinical interest.

KW - Hydroxyapatite

KW - Bioceramics

KW - Porous

KW - Freeze-casting

UR - http://www.scopus.com/inward/record.url?scp=64249134629&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/j.actbio.2008.11.009

U2 - 10.1016/j.actbio.2008.11.009

DO - 10.1016/j.actbio.2008.11.009

M3 - Article

VL - 5

SP - 1319

EP - 1327

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 4

ER -