Fabrication of BioFET Linear Array for Detection of Protein Interactions

L Wang; Pedro Estrela; E Huq; P Li; S Thomas; P Ko Ferrigno; D Paul; P Adkin; P Migliorato

doi:10.1016/j.mee.2009.11.148

Fabrication of BioFET Linear Array for Detection of Protein Interactions

L Wang
, Pedro Estrela
, E Huq
, P Li
, S Thomas
, P Ko Ferrigno
, D Paul
, P Adkin
, P Migliorato

Department of Electronic & Electrical Engineering

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Abstract

An extended-gate MOSFETs (metal–oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.

Original language	English
Pages (from-to)	753-755
Number of pages	3
Journal	Microelectronic Engineering
Volume	87
Issue number	5-8
DOIs	https://doi.org/10.1016/j.mee.2009.11.148
Publication status	Published - May 2010
Event	35th International Conference on Micro & Nano Engineering (MNE) - Ghent, Belgium Duration: 28 Sept 2009 → 1 Oct 2009

Bibliographical note

The 35th International Conference on Micro- and Nano-Engineering (MNE), The 35th International Conference on Micro- and Nano-Engineering (MNE)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.mee.2009.11.148

Cite this

@article{483e48cb690c43088853bb4a99213a18,

title = "Fabrication of BioFET Linear Array for Detection of Protein Interactions",

abstract = "An extended-gate MOSFETs (metal{\textendash}oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.",

author = "L Wang and Pedro Estrela and E Huq and P Li and S Thomas and \{Ko Ferrigno\}, P and D Paul and P Adkin and P Migliorato",

note = "The 35th International Conference on Micro- and Nano-Engineering (MNE), The 35th International Conference on Micro- and Nano-Engineering (MNE); 35th International Conference on Micro \& Nano Engineering (MNE) ; Conference date: 28-09-2009 Through 01-10-2009",

year = "2010",

month = may,

doi = "10.1016/j.mee.2009.11.148",

language = "English",

volume = "87",

pages = "753--755",

journal = "Microelectronic Engineering",

issn = "0167-9317",

publisher = "Elsevier B.V.",

number = "5-8",

}

TY - JOUR

T1 - Fabrication of BioFET Linear Array for Detection of Protein Interactions

AU - Wang, L

AU - Estrela, Pedro

AU - Huq, E

AU - Li, P

AU - Thomas, S

AU - Ko Ferrigno, P

AU - Paul, D

AU - Adkin, P

AU - Migliorato, P

N1 - The 35th International Conference on Micro- and Nano-Engineering (MNE), The 35th International Conference on Micro- and Nano-Engineering (MNE)

PY - 2010/5

Y1 - 2010/5

N2 - An extended-gate MOSFETs (metal–oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.

AB - An extended-gate MOSFETs (metal–oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.

UR - https://www.scopus.com/pages/publications/76949100384

UR - http://dx.doi.org/10.1016/j.mee.2009.11.148

U2 - 10.1016/j.mee.2009.11.148

DO - 10.1016/j.mee.2009.11.148

M3 - Article

SN - 0167-9317

VL - 87

SP - 753

EP - 755

JO - Microelectronic Engineering

JF - Microelectronic Engineering

IS - 5-8

T2 - 35th International Conference on Micro & Nano Engineering (MNE)

Y2 - 28 September 2009 through 1 October 2009

ER -

Fabrication of BioFET Linear Array for Detection of Protein Interactions

Abstract

Bibliographical note

UN SDGs

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