Fabrication of BioFET Linear Array for Detection of Protein Interactions

L Wang, Pedro Estrela, E Huq, P Li, S Thomas, P Ko Ferrigno, D Paul, P Adkin, P Migliorato

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)

Abstract

An extended-gate MOSFETs (metal–oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK.
Original languageEnglish
Pages (from-to)753-755
Number of pages3
JournalMicroelectronic Engineering
Volume87
Issue number5-8
DOIs
Publication statusPublished - May 2010
Event35th International Conference on Micro & Nano Engineering (MNE) - Ghent, Belgium
Duration: 28 Sep 20091 Oct 2009

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