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Nanogap sensors have a wide range of applications as they can provide accurate direct detection of biomolecules through impedimetric or amperometric signals. Signal response from nanogap sensors is dependent on both the electrode spacing and surface area. However, creating large surface area nanogap sensors presents several challenges during fabrication. We show two different approaches to achieve both horizontal and vertical coplanar nanogap geometries. In the first method we use electron-beam lithography (EBL) to pattern an 11 mm long serpentine nanogap (215 nm) between two electrodes. For the second method we use inductively-coupled plasma (ICP) reactive ion etching (RIE) to create a channel in a silicon substrate, optically pattern a buried 1.0 mm 1.5 mm electrode before anodically bonding a second identical electrode, patterned on glass, directly above. The devices have a wide range of applicability in different sensing techniques with the large area nanogaps presenting advantages over other devices of the same family. As a case study we explore the detection of peptide nucleic acid (PNA)􀀀DNA binding events using dielectric spectroscopy with the horizontal coplanar device.
Original languageEnglish
Article number2128
Number of pages16
Issue number12
Publication statusPublished - 14 Dec 2016


  • Nanogap junctions
  • anodic bonding
  • capacitance
  • Biosensors


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  • Hitachi S4300 SEM

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    Department of Chemical Engineering

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  • Plasma Therm 790 PECVD

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