Extended-amygdala intrinsic functional connectivity networks: A population study

Samuel C. Berry, Richard G. Wise, Andrew D. Lawrence, Thomas M. Lancaster

Research output: Contribution to journalArticlepeer-review

Abstract

Pre-clinical and human neuroimaging research implicates the extended-amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance-use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised a large sample (n > 1,000 healthy young adult humans) to compare the intrinsic functional connectivity networks (ICNs) of the BST and CeA using task-free functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. We assessed whether inter-individual differences within these ICNs were related to two principal components representing negative disposition and alcohol use. Building on recent primate evidence, we tested whether within BST-CeA intrinsic functional connectivity (iFC) was heritable and further examined co-heritability with our principal components. We demonstrate the BST and CeA to have discrete, but largely overlapping ICNs similar to previous findings. We found no evidence that within BST—CeA iFC was heritable; however, post hoc analyses found significant BST iFC heritability with the broader superficial and centromedial amygdala regions. There were no significant correlations or co-heritability associations with our principal components either across the ICNs or for specific BST-Amygdala iFC. Possible differences in phenotype associations across task-free, task-based, and clinical fMRI are discussed, along with suggestions for more causal investigative paradigms that make use of the now well-established ExtA ICNs.


This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 665992 

Original languageEnglish
Pages (from-to)1594-1616
JournalHuman Brain Mapping
Volume42
Issue number6
Early online date12 Dec 2020
DOIs
Publication statusPublished - 15 Apr 2021

Keywords

  • alcohol use
  • bed nucleus of the stria terminalis (BST/BNST)
  • central nucleus of the amygdala (CeA)
  • dispositional negativity
  • extended amygdala (ExtA)
  • intrinsic functional connectivity (iFC)
  • task-free functional magnetic resonance imaging (tf-fMRI)

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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