TY - JOUR
T1 - Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals
AU - Martínez-Pacheco, Mónica
AU - Tenorio, Mariela
AU - Almonte, Laura
AU - Fajardo, Vicente
AU - Godínez, Alan
AU - Fernández, Diego
AU - Cornejo-Páramo, Paola
AU - Díaz-Barba, Karina
AU - Halbert, Jean
AU - Liechti, Angelica
AU - Székely, Tamas
AU - Urrutia, Araxi O.
AU - Cortez, Diego
PY - 2020/11/3
Y1 - 2020/11/3
N2 - Placental mammals present 180 million-year-old Y chromosomes that have retained a handful of dosage-sensitive genes. However, the expression evolution of Y-linked genes across placental groups has remained largely unexplored. Here, we expanded the number of Y gametolog sequences by analyzing ten additional species from previously unexplored groups. We detected seven remarkably conserved genes across 25 placental species with known Y repertoires. We then used RNA-seq data from 17 placental mammals to unveil the expression evolution of XY gametologs. We found that Y gametologs followed, on average, a 3-fold expression loss and that X gametologs also experienced some expression reduction, particularly in primates. Y gametologs gained testis specificity through an accelerated expression decay in somatic tissues. Moreover, despite the substantial expression decay of Y genes, the combined expression of XY gametologs in males is higher than that of both X gametologs in females. Finally, our work describes several features of the Y chromosome in the last common mammalian ancestor.
AB - Placental mammals present 180 million-year-old Y chromosomes that have retained a handful of dosage-sensitive genes. However, the expression evolution of Y-linked genes across placental groups has remained largely unexplored. Here, we expanded the number of Y gametolog sequences by analyzing ten additional species from previously unexplored groups. We detected seven remarkably conserved genes across 25 placental species with known Y repertoires. We then used RNA-seq data from 17 placental mammals to unveil the expression evolution of XY gametologs. We found that Y gametologs followed, on average, a 3-fold expression loss and that X gametologs also experienced some expression reduction, particularly in primates. Y gametologs gained testis specificity through an accelerated expression decay in somatic tissues. Moreover, despite the substantial expression decay of Y genes, the combined expression of XY gametologs in males is higher than that of both X gametologs in females. Finally, our work describes several features of the Y chromosome in the last common mammalian ancestor.
KW - dosage compensation mechanisms
KW - gene expression levels
KW - placental mammals
KW - sex chromosomes
KW - Y chromosome
UR - http://www.scopus.com/inward/record.url?scp=85096456694&partnerID=8YFLogxK
U2 - 10.1093/gbe/evaa173
DO - 10.1093/gbe/evaa173
M3 - Article
C2 - 32790864
AN - SCOPUS:85096456694
VL - 12
SP - 2015
EP - 2028
JO - Genome biology and evolution
JF - Genome biology and evolution
SN - 1759-6653
IS - 11
ER -