Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.

Roy P. Lester; Travis Bham; Thomas W. Bousfield; William Lewis; Jason E. Camp

doi:10.1021/acs.joc.6b02315

Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.

Roy P. Lester, Travis Bham, Thomas W. Bousfield, William Lewis, Jason E. Camp

Research output: Contribution to journal › Article › peer-review

20 Citations (SciVal)

Abstract

The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2'-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivs. from a single 2-trichloromethylbenzoxazole starting material. [on SciFinder(R)]

Original language	English
Pages (from-to)	12472-12477
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	81
Issue number	24
Early online date	6 Dec 2016
DOIs	https://doi.org/10.1021/acs.joc.6b02315
Publication status	Published - 16 Dec 2016

Bibliographical note

M1 - Copyright (C) 2018 American Chemical Society (ACS). All Rights Reserved.

CAPLUS AN 2016:1994177(Journal; Online Computer File)

Keywords

substituted benzoxazole prepn trichloromethylbenzoxazole substitution nucleophile

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10.1021/acs.joc.6b02315

http://eprints.nottingham.ac.uk/39891/

Cite this

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title = "Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.",

abstract = "The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2'-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivs. from a single 2-trichloromethylbenzoxazole starting material. [on SciFinder(R)]",

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author = "Lester, {Roy P.} and Travis Bham and Bousfield, {Thomas W.} and William Lewis and Camp, {Jason E.}",

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doi = "10.1021/acs.joc.6b02315",

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T1 - Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.

AU - Lester, Roy P.

AU - Bham, Travis

AU - Bousfield, Thomas W.

AU - Lewis, William

AU - Camp, Jason E.

PY - 2016/12/16

Y1 - 2016/12/16

N2 - The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2'-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivs. from a single 2-trichloromethylbenzoxazole starting material. [on SciFinder(R)]

AB - The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2'-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivs. from a single 2-trichloromethylbenzoxazole starting material. [on SciFinder(R)]

KW - substituted benzoxazole prepn trichloromethylbenzoxazole substitution nucleophile

U2 - 10.1021/acs.joc.6b02315

DO - 10.1021/acs.joc.6b02315

M3 - Article

SN - 0022-3263

VL - 81

SP - 12472

EP - 12477

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 24

ER -

Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.

Abstract

Bibliographical note

Keywords

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