Exploring the Reactivity of 2-Trichloromethylbenzoxazoles for Access to Substituted Benzoxazoles.

Roy P. Lester, Travis Bham, Thomas W. Bousfield, William Lewis, Jason E. Camp

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The reactivity of 2-trichloromethylbenzoxazoles toward various nucleophiles, under metal-free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2'-position of the benzoxazoles using the same starting materials/reagents. This approach allows for the controlled synthesis of a variety of key derivs. from a single 2-trichloromethylbenzoxazole starting material. [on SciFinder(R)]
Original languageEnglish
Pages (from-to)12472-12477
Number of pages6
JournalJournal of Organic Chemistry
Issue number24
Early online date6 Dec 2016
Publication statusPublished - 16 Dec 2016


  • substituted benzoxazole prepn trichloromethylbenzoxazole substitution nucleophile

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