Exploring the effects of cigarette smoking on inflammatory bowel disease using mendelian randomization

Daniel P. Jones; Tom G. Richardson; George Davey Smith; David Gunnell; Marcus R. Munafò; Robyn E. Wootton

doi:10.1093/crocol/otaa018

Exploring the effects of cigarette smoking on inflammatory bowel disease using mendelian randomization

Daniel P. Jones, Tom G. Richardson, George Davey Smith, David Gunnell, Marcus R. Munafò, Robyn E. Wootton

Vice Chancellor's Office

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

Abstract

Background: Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD).

Methods: We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes.

Results: In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD.

Conclusion: Overall, our results suggest that smoking does not causally influence the risk of IBD. Lay summary A study investigating the effect of smoking on the risk of developing inflammatory bowel disease using observational and genetic tools. Despite strong observed associations, our overall results suggest smoking does not affect the risk of developing inflammatory bowel disease.

Original language	English
Article number	otaa018
Journal	Crohn's and Colitis 360
Volume	2
Issue number	1
DOIs	https://doi.org/10.1093/crocol/otaa018
Publication status	Published - 1 Jan 2020

Acknowledgements

We are grateful to the participants of the UK Biobank and the individuals who contributed to each of the previous GWAS analyses conducted as well as all the research staff who worked on the data collection. This research has been conducted using the UK Biobank Resource under Application Number 9142.

Funding

REW, TGR, GDS and MRM are all members of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the Medical Research Council: http://www.mrc.ac.uk [MC_UU_00011/1, MC_UU_00011/7]. This study was supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care. This research has been conducted using the UK Biobank Resource under Application Number 9142.

Keywords

Inflammatory bowel disease
Mendelian randomization
Smoking
UK Biobank

ASJC Scopus subject areas

Gastroenterology

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10.1093/crocol/otaa018Licence: CC BY

Cite this

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abstract = "Background: Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods: We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes. Results: In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD. Conclusion: Overall, our results suggest that smoking does not causally influence the risk of IBD. Lay summary A study investigating the effect of smoking on the risk of developing inflammatory bowel disease using observational and genetic tools. Despite strong observed associations, our overall results suggest smoking does not affect the risk of developing inflammatory bowel disease.",

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AU - Wootton, Robyn E.

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N2 - Background: Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods: We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes. Results: In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD. Conclusion: Overall, our results suggest that smoking does not causally influence the risk of IBD. Lay summary A study investigating the effect of smoking on the risk of developing inflammatory bowel disease using observational and genetic tools. Despite strong observed associations, our overall results suggest smoking does not affect the risk of developing inflammatory bowel disease.

AB - Background: Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). Methods: We used observational techniques followed by Mendelian randomization to explore whether smoking is a causal factor in the development of IBD and its subtypes. Results: In those who have ever smoked, we observed increased risk of IBD and, in current smokers, we observed increased risk of Crohn disease and decreased risk of ulcerative colitis. However, our Mendelian randomization analyses found little evidence that smoking affects the development of IBD. Conclusion: Overall, our results suggest that smoking does not causally influence the risk of IBD. Lay summary A study investigating the effect of smoking on the risk of developing inflammatory bowel disease using observational and genetic tools. Despite strong observed associations, our overall results suggest smoking does not affect the risk of developing inflammatory bowel disease.

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Exploring the effects of cigarette smoking on inflammatory bowel disease using mendelian randomization

Abstract

Acknowledgements

Funding

Keywords

ASJC Scopus subject areas

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