Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

Kurt Polidano, Benjamin G. Reed-Berendt, Anaïs Basset, Andrew J.A. Watson, Jonathan M.J. Williams, Louis C. Morrill

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

Original languageEnglish
Pages (from-to)6716-6719
Number of pages4
JournalOrganic Letters
Volume19
Issue number24
DOIs
Publication statusPublished - 15 Dec 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Polidano, K., Reed-Berendt, B. G., Basset, A., Watson, A. J. A., Williams, J. M. J., & Morrill, L. C. (2017). Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry. Organic Letters, 19(24), 6716-6719. https://doi.org/10.1021/acs.orglett.7b03441