Exploring rhodium-catalysed conjugate addition of chiral alkenylboronates using chiral olefin ligands

Christopher G Frost; Hannah J Edwards; Stephen D Penrose; R Gleave

doi:10.1055/s-0030-1258203

Exploring rhodium-catalysed conjugate addition of chiral alkenylboronates using chiral olefin ligands

Christopher G Frost, Hannah J Edwards, Stephen D Penrose, R Gleave

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (SciVal)

Abstract

The rhodium-catalysed addition of chiral alkenylboron reagents to prochiral alpha,beta-unsaturated carbonyl acceptors are demonstrated to proceed under ligand control. The highest activities were obtained with chiral olefin ligands and the configuration of the new stereocentre can be predicted by using established models.

Original language	English
Pages (from-to)	3243-3247
Number of pages	5
Journal	Synthesis
Volume	2010
Issue number	19
DOIs	https://doi.org/10.1055/s-0030-1258203
Publication status	Published - Oct 2010

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10.1055/s-0030-1258203

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title = "Exploring rhodium-catalysed conjugate addition of chiral alkenylboronates using chiral olefin ligands",

abstract = "The rhodium-catalysed addition of chiral alkenylboron reagents to prochiral alpha,beta-unsaturated carbonyl acceptors are demonstrated to proceed under ligand control. The highest activities were obtained with chiral olefin ligands and the configuration of the new stereocentre can be predicted by using established models.",

author = "Frost, {Christopher G} and Edwards, {Hannah J} and Penrose, {Stephen D} and R Gleave",

year = "2010",

month = oct,

doi = "10.1055/s-0030-1258203",

language = "English",

volume = "2010",

pages = "3243--3247",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

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T1 - Exploring rhodium-catalysed conjugate addition of chiral alkenylboronates using chiral olefin ligands

AU - Frost, Christopher G

AU - Edwards, Hannah J

AU - Penrose, Stephen D

AU - Gleave, R

PY - 2010/10

Y1 - 2010/10

N2 - The rhodium-catalysed addition of chiral alkenylboron reagents to prochiral alpha,beta-unsaturated carbonyl acceptors are demonstrated to proceed under ligand control. The highest activities were obtained with chiral olefin ligands and the configuration of the new stereocentre can be predicted by using established models.

AB - The rhodium-catalysed addition of chiral alkenylboron reagents to prochiral alpha,beta-unsaturated carbonyl acceptors are demonstrated to proceed under ligand control. The highest activities were obtained with chiral olefin ligands and the configuration of the new stereocentre can be predicted by using established models.

UR - http://www.scopus.com/inward/record.url?scp=77957129734&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1055/s-0030-1258203

U2 - 10.1055/s-0030-1258203

DO - 10.1055/s-0030-1258203

M3 - Article

SN - 0039-7881

VL - 2010

SP - 3243

EP - 3247

JO - Synthesis

JF - Synthesis

IS - 19

ER -

Exploring rhodium-catalysed conjugate addition of chiral alkenylboronates using chiral olefin ligands

Abstract

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500 MHZ NMR SPECTROMETER TO SUPPORT ORGANIC, BIO-ORGANIC AND INORGANIC CHEMISTRY

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Exploring rhodium-catalysed conjugate addition of chiral alkenylboronates using chiral olefin ligands

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