A series of salts, some of which are ionic liquids, are prepared from cations and anions drawn from Active Pharmaceutical Ingredients (APIs) and Generally Recognized As Safe (GRAS) materials. Using the solid-state structures of the crystalline salts as a basis, an anti-crystal engineering approach to the preparation of “Active Ionic Liquids” (AILs) is explored.
Dean, P. M., Turanjanin, J., Yoshizawa-Fujita, M., MacFarlane, D. R., & Scott, J. L. (2009). Exploring an anti-crystal engineering approach to the preparation of pharmaceutically active ionic liquids. Crystal Growth and Design, 9(2), 1137-1145. https://doi.org/10.1021/cg8009496