Exploitation of Feedback in Enzyme-catalysed Reactions

Támás Bánsági, Annette F. Taylor

Research output: Contribution to journalReview articlepeer-review

2 Citations (SciVal)

Abstract

Some cellular systems, such as yeast, bacteria and slime mould, display dynamic behavior including switches and rhythms driven by feedback in enzyme-catalysed reactions. The mechanisms of these processes have been well investigated and recent attention has turned to generating similar responses in synthetic biocatalytic systems, with a view to creating bioinspired analogues for applications. Here we discuss how feedback arises in the reaction mechanisms of some enzyme-catalyzed reactions in vitro, the behaviour obtained and the emerging applications. These autocatalytic reactions may provide insights into behaviour in cellular systems as well as new methods for drug delivery, sensing and repair that can be exploited in living systems.

Original languageEnglish
Pages (from-to)706-713
Number of pages8
JournalIsrael Journal of Chemistry
Volume58
Issue number6
Early online date29 Mar 2018
DOIs
Publication statusPublished - 30 Jun 2018

Bibliographical note

Funding Information:
The authors acknowledge support from EPSRC grant EP/ K030574/2.

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Autocatalysis
  • bioinspired
  • enzymes
  • reaction networks
  • systems chemistry

ASJC Scopus subject areas

  • Chemistry(all)

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