Experimental and molecular orbital calculational study of the stereoselective Horner-Wittig reaction with phosphine oxides: Control of stereoselectivity by lithium

David R. Armstrong; Donald Barr; Matthew G. Davidson; Gordon Hutton; Peter O'Brien; Ronald Snaith; Stuart Warren

doi:10.1016/S0022-328X(96)06771-X

Experimental and molecular orbital calculational study of the stereoselective Horner-Wittig reaction with phosphine oxides: Control of stereoselectivity by lithium

David R. Armstrong, Donald Barr, Matthew G. Davidson, Gordon Hutton, Peter O'Brien, Ronald Snaith, Stuart Warren

Research output: Contribution to journal › Article › peer-review

29 Citations (SciVal)

Abstract

Ab initio calculations have been used to determine the possible structure of lithium derivatives of phosphine oxides in THF: extension of these calculations to the docking of a carbonyl compound onto such a lithium derivative suggests an explanation for the anti selectivity of the Horner-Wittig reaction.

Original language	English
Pages (from-to)	29-33
Number of pages	5
Journal	Journal of Organometallic Chemistry
Volume	529
Issue number	1-2
DOIs	https://doi.org/10.1016/S0022-328X(96)06771-X
Publication status	Published - 15 Feb 1997

Keywords

Ab initio calculations
Horner-Wittig reaction
Lithiated phosphine oxides
Stereoeselectivity

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/S0022-328X(96)06771-X

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Experimental and molecular orbital calculational study of the stereoselective Horner-Wittig reaction with phosphine oxides: Control of stereoselectivity by lithium. / Armstrong, David R.; Barr, Donald; Davidson, Matthew G. et al.
In: Journal of Organometallic Chemistry, Vol. 529, No. 1-2, 15.02.1997, p. 29-33.

Research output: Contribution to journal › Article › peer-review

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AU - Davidson, Matthew G.

AU - Hutton, Gordon

AU - O'Brien, Peter

AU - Snaith, Ronald

AU - Warren, Stuart

PY - 1997/2/15

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KW - Stereoeselectivity

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Experimental and molecular orbital calculational study of the stereoselective Horner-Wittig reaction with phosphine oxides: Control of stereoselectivity by lithium

Abstract

Keywords

ASJC Scopus subject areas

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