Expedient Approach to Chiral Cyclobutanones:  Asymmetric Synthesis of Cyclobut-G

Benjamin Darses; Andrew Greene; Susannah Coote; Jean-Francois Poisson

doi:10.1021/ol702977x

Expedient Approach to Chiral Cyclobutanones: Asymmetric Synthesis of Cyclobut-G

Benjamin Darses, Andrew Greene, Susannah Coote, Jean-Francois Poisson

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

30 Citations (SciVal)

Abstract

An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.

Original language	English
Pages (from-to)	821-824
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	5
DOIs	https://doi.org/10.1021/ol702977x
Publication status	Published - 13 Feb 2008

Access to Document

10.1021/ol702977x

https://pubs.acs.org/doi/full/10.1021/ol702977x

Cite this

@article{e1df9c20ad1d48e19bb8adcd7c8663d3,

title = "Expedient Approach to Chiral Cyclobutanones: Asymmetric Synthesis of Cyclobut-G",

abstract = "An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.",

author = "Benjamin Darses and Andrew Greene and Susannah Coote and Jean-Francois Poisson",

year = "2008",

month = feb,

day = "13",

doi = "10.1021/ol702977x",

language = "English",

volume = "10",

pages = "821--824",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Expedient Approach to Chiral Cyclobutanones: Asymmetric Synthesis of Cyclobut-G

AU - Darses, Benjamin

AU - Greene, Andrew

AU - Coote, Susannah

AU - Poisson, Jean-Francois

PY - 2008/2/13

Y1 - 2008/2/13

N2 - An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.

AB - An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved.

U2 - 10.1021/ol702977x

DO - 10.1021/ol702977x

M3 - Article

SN - 1523-7060

VL - 10

SP - 821

EP - 824

JO - Organic Letters

JF - Organic Letters

IS - 5

ER -

Expedient Approach to Chiral Cyclobutanones: Asymmetric Synthesis of Cyclobut-G

Abstract

Access to Document

Fingerprint

Cite this