Abstract
Metabolism of meta-bromobenzoic acid by the blocked mutant Ralstonia eutrophus B9 affords an enantiopure dearomatised halodiene-diol which we demonstrate is a versatile chiron for organic synthesis. The presence of the halogen leads to reactivity that is distinct to that observed for the non-halogenated analogue and also serves as a synthetic handle for further functionalisation.
Original language | English |
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Pages (from-to) | 3920-3928 |
Number of pages | 9 |
Journal | Organic and Biomolecular Chemistry |
Volume | 9 |
Issue number | 10 |
DOIs | |
Publication status | Published - 21 May 2011 |