Abstract
Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomised controlled trial demonstrates that regular exercise completely maintains serum concentrations of the active vitamin D metabolite 1,25(OH)2D¬3 over winter and may ameliorate the decline in 25(OH)D status in overweight men and women, even without weight loss. The binding of 1,25(OH)2D¬3 to the vitamin D receptor mediates the crucial role for vitamin D in the healthy function of multiple organ systems and vitamin D supplementation does not impact circulating 1,25(OH)2D3. Thus, the VitaDEx study provides causal evidence that exercise plays an important role in vitamin D metabolism that is distinct from the effects of oral supplementation.
| Original language | English |
|---|---|
| Journal | Advanced Science |
| Early online date | 11 May 2025 |
| DOIs | |
| Publication status | E-pub ahead of print - 11 May 2025 |
Data Availability Statement
All other data needed to evaluate the conclusions in the paper are available through the University of Bath Data Archive (https://doi.org/10.15125/BATH-01420), that is, all data reported in the present study at an anonymized participant level. These data will remain in the Data Archive indefinitely. Any additional information required to reanalyze the data reported in this paper is available from the corresponding authors upon request, and transfer agreements will be established as required.Funding
Biotechnology and Biological Sciences Research Council. Grant Number: BB/R018928/1; NIHR Cambridge Biomedical Research Centre. Grant Number: NIHR203312; Wellcome Trust. Grant Number: 203141/A/16/Z
| Funders | Funder number |
|---|---|
| Biotechnology and Biological Sciences Research Council |
