Exercise dose-response of the V(E)/VCO(2) slope in postmenopausal women in the DREW study

S A Anaya, T S Church, S N Blair, J N Myers, Conrad P Earnest

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PURPOSE: Being overweight/obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V(E)/VCO(2) slope, which is predictive of mortality in patients with CHF. Although the V(E)/VCO(2) slope is well established in CHF patients, little is known regarding interventions for "at-risk" populations. METHODS: We examined the V(E)/VCO(2) slope in 401 sedentary, overweight, moderately hypertensive women randomized to 6 m of nonexercise (control) or 4 kcal x kg(-1) x wk(-1) (KKW), 8 KKW, or 12 KKW of exercise at an intensity corresponding to 50% of baseline VO(2max). We examined trends in exercise treatment dose versus change in mean V(E)/VCO(2) slope using a linear regression model (KKW vs V(E)/VCO(2) slope) and a linear mixed model. RESULTS: Regression analysis showed a significant trend for a reduction in the V(E)/VCO(2) slope from baseline (mean +/- SD: 32.6 +/- 6.3; P < 0.004). When expressed as mean change (95% confidence interval (CI)) from baseline, we observed significant reductions in the V(E)/VCO(2) slope for the 8-KKW (-1.14; 95% CI, -1.5 to -0.2) and 12-KKW (-1.67; 95% CI, -2.3 to -0.3) groups. No significant effect was noted for the 4-KKW (-0.4; 95% CI, -1.2 to 0.15) group. CONCLUSION: Moderate-intensity aerobic exercise at doses of 8 KKW or greater seems to present an adequate dose of exercise to promote small but significant reductions in the V(E)/VCO(2) slope in postmenopausal women who exhibit risk factors associated with the development of CHF.
Original languageEnglish
Pages (from-to)971-976
Number of pages6
JournalMedicine and Science in Sports and Exercise
Issue number5
Publication statusPublished - May 2009

Bibliographical note

Anaya, Stephanie A Church, Timothy S Blair, Steven N Myers, Jonathan N Earnest, Conrad P HL-66262/HL/NHLBI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Medicine and science in sports and exercise Med Sci Sports Exerc. 2009 May;41(5):971-6. Exercise and Health


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