Exercise capacity and body composition as predictors of mortality among men with diabetes

T S Church, Y J Cheng, Conrad P Earnest, C E Barlow, L W Gibbons, E L Priest, S N Blair

Research output: Contribution to journalArticlepeer-review

330 Citations (Scopus)

Abstract

OBJECTIVE: To quantify the relation of fitness to mortality among men with diabetes, adjusted for BMI and within levels of BMI.

RESEARCH DESIGN AND METHODS: In this observational cohort study, we calculated all-cause death rates in men with diabetes across quartiles of fitness and BMI categories. Study participants were 2,196 men with diabetes (average age 49.3 years, SD 9.5) who underwent a medical examination, including a maximal exercise test, during 1970 to 1995, with mortality follow-up to 31 December 1996.

RESULTS: We identified 275 deaths during 32,161 person-years of observation. Risk of all-cause mortality was inversely related to fitness. For example, in the fully adjusted model, the risk of mortality was 4.5 (2.6-7.6), 2.8 (1.6-4.7), and 1.6 (0.93-2.76) for the first, second, and third fitness quartiles, respectively, with the fourth quartile (highest fitness level) as the referent (P for trend < 0.0001). There was no significant trend across BMI categories for mortality after adjustment for fitness. Similar results were found when the fitness-mortality relation was examined within levels of body composition. In normal-weight men with diabetes, the relative risks of mortality were 6.6 (2.8-15.0), 3.2 (1.4-7.0), and 2.2 (1.1-4.6) for the first, second, and third quartiles of fitness, respectively, as compared with the fourth quartile (P for trend < 0.0001). We found similar results in the overweight and obese weight categories.

CONCLUSIONS: There was a steep inverse gradient between fitness and mortality in this cohort of men with documented diabetes, and this association was independent of BMI.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalDiabetes Care
Volume27
Issue number1
DOIs
Publication statusPublished - 2004

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