Evolutionary genetics of maternal effects

Jason B. Wolf, Michael J. Wade

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Maternal genetic effects (MGEs), where genes expressed by mothers affect the phenotype of their offspring, are important sources of phenotypic diversity in a myriad of organisms. We use a single-locus model to examine how MGEs contribute patterns of heritable and nonheritable variation and influence evolutionary dynamics in randomly mating and inbreeding populations. We elucidate the influence of MGEs by examining the offspring genotype-phenotype relationship, which determines how MGEs affect evolutionary dynamics in response to selection on offspring phenotypes. This approach reveals important results that are not apparent from classic quantitative genetic treatments of MGEs. We show that additive and dominance MGEs make different contributions to evolutionary dynamics and patterns of variation, which are differentially affected by inbreeding. Dominance MGEs make the offspring genotype-phenotype relationship frequency dependent, resulting in the appearance of negative frequency-dependent selection, while additive MGEs contribute a component of parent-of-origin dependent variation. Inbreeding amplifies the contribution of MGEs to the additive genetic variance and, therefore enhances their evolutionary response. Considering evolutionary dynamics of allele frequency change on an adaptive landscape, we show that this landscape differs from the mean fitness surface, and therefore, under some condition, fitness peaks can exist but not be "available" to the evolving population.

LanguageEnglish
Pages827-839
Number of pages13
JournalEvolution
Volume70
Issue number4
DOIs
StatusPublished - 1 Apr 2016

Fingerprint

maternal effect
Inbreeding
phenotype
inbreeding
Phenotype
dominance (genetics)
genotype
fitness
Genotype
genetic effect
Maternal Inheritance
quantitative genetics
genetic variance
Gene Frequency
Population
gene frequency
allele
loci
gene
organisms

Keywords

  • Adaptive landscape
  • Dominance
  • Frequency dependent selection
  • Kin selection
  • Social effects

Cite this

Evolutionary genetics of maternal effects. / Wolf, Jason B.; Wade, Michael J.

In: Evolution, Vol. 70, No. 4, 01.04.2016, p. 827-839.

Research output: Contribution to journalArticle

Wolf, Jason B. ; Wade, Michael J. / Evolutionary genetics of maternal effects. In: Evolution. 2016 ; Vol. 70, No. 4. pp. 827-839.
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