Evolution of MRSA during hospital transmission and intercontinental spread

S R Harris; Edward J Feil; M T G Holden; M A Quail; E K Nickerson; N Chantratita; S Gardete; A Tavares; N Day; J A Lindsay; J D Edgeworth; H de Lencastre; J Parkhill; S J Peacock; S D Bentley

doi:10.1126/science.1182395

Evolution of MRSA during hospital transmission and intercontinental spread

S R Harris, Edward J Feil, M T G Holden, M A Quail, E K Nickerson, N Chantratita, S Gardete, A Tavares, N Day, J A Lindsay, J D Edgeworth, H de Lencastre, J Parkhill, S J Peacock, S D Bentley

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

937 Citations (SciVal)

Abstract

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

Original language	English
Pages (from-to)	469-474
Number of pages	6
Journal	Science
Volume	327
Issue number	5964
DOIs	https://doi.org/10.1126/science.1182395
Publication status	Published - 22 Jan 2010

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Harris, S. R., Feil, E. J., Holden, M. T. G., Quail, M. A., Nickerson, E. K., Chantratita, N., Gardete, S., Tavares, A., Day, N., Lindsay, J. A., Edgeworth, J. D., de Lencastre, H., Parkhill, J., Peacock, S. J., & Bentley, S. D. (2010). Evolution of MRSA during hospital transmission and intercontinental spread. Science, 327(5964), 469-474. https://doi.org/10.1126/science.1182395

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AU - Harris, S R

AU - Feil, Edward J

AU - Holden, M T G

AU - Quail, M A

AU - Nickerson, E K

AU - Chantratita, N

AU - Gardete, S

AU - Tavares, A

AU - Day, N

AU - Lindsay, J A

AU - Edgeworth, J D

AU - de Lencastre, H

AU - Parkhill, J

AU - Peacock, S J

AU - Bentley, S D

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Evolution of MRSA during hospital transmission and intercontinental spread

Abstract

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