Evidence that the human X chromosome is enriched for male-specific but not female-specific genes

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Abstract

There is increasing evidence that X chromosomes have an unusual complement of genes, especially genes that have sex-specific expression. However, whereas in worm and fly the X chromosome has a dearth of male-specific genes, in mice genes that are uniquely expressed in spermatogonia are especially abundant on the X chromosome. Is this latter enrichment true for nongermline, male-specific genes in mammals, and is it found also for female-specific genes? Here, using SAGE data, we show (1) that tissue-specific genes tend to be more abundant on the human X chromosome, (2) that, controlling for this effect, genes expressed exclusively in prostate are enriched on the human X chromosome, and (3) that genes expressed exclusively in mammary gland and ovary are not so enriched. This we propose is consistent with Rice's model of the evolution of sexually antagonistic alleles.
Original languageEnglish
Pages (from-to)1113-1116
Number of pages4
JournalMolecular Biology and Evolution
Volume20
Issue number7
Early online date30 May 2003
DOIs
Publication statusPublished - 7 Jul 2003

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