Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

Mark McMullan, Anastasia Gardiner, Kate Bailey, Eric Kemen, Ben J Ward, Volkan Cevik, Alexandre Robert-Seilaniantz, Torsten Schultz-Larsen, Alexi Balmuth, Eric Holub, Cock van Oosterhout, Jonathan D G Jones

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ∼1%. Despite this divergence, their genomes are mosaic-like, with ∼25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.

Original languageEnglish
Article numbere04550
JournaleLife
Volume4
DOIs
Publication statusPublished - 27 Feb 2015

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Candida
Host Specificity
Immunity
Parasites
Genes
Pathogens
Yeast
Fish
Infection
Genome
Brassicaceae
Finches
Cichlids
Butterflies
Helianthus
Eukaryota
Yeasts
Experiments
Population

Keywords

  • Alleles
  • Animals
  • DNA, Plant
  • Genome
  • Host Specificity
  • Immunity
  • Nucleotides
  • Oomycetes
  • Parasites
  • Phylogeny
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Recombination, Genetic
  • Sequence Alignment
  • Virulence
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. / McMullan, Mark; Gardiner, Anastasia; Bailey, Kate; Kemen, Eric; Ward, Ben J; Cevik, Volkan; Robert-Seilaniantz, Alexandre; Schultz-Larsen, Torsten; Balmuth, Alexi; Holub, Eric; van Oosterhout, Cock; Jones, Jonathan D G.

In: eLife, Vol. 4, e04550, 27.02.2015.

Research output: Contribution to journalArticle

McMullan, M, Gardiner, A, Bailey, K, Kemen, E, Ward, BJ, Cevik, V, Robert-Seilaniantz, A, Schultz-Larsen, T, Balmuth, A, Holub, E, van Oosterhout, C & Jones, JDG 2015, 'Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite', eLife, vol. 4, e04550. https://doi.org/10.7554/eLife.04550
McMullan, Mark ; Gardiner, Anastasia ; Bailey, Kate ; Kemen, Eric ; Ward, Ben J ; Cevik, Volkan ; Robert-Seilaniantz, Alexandre ; Schultz-Larsen, Torsten ; Balmuth, Alexi ; Holub, Eric ; van Oosterhout, Cock ; Jones, Jonathan D G. / Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. In: eLife. 2015 ; Vol. 4.
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