Evidence against the selfish operon theory

C Pal, L D Hurst

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

According to the selfish operon hypothesis, the clustering of genes and their subsequent organization into operons is beneficial for the constituent genes because it enables the horizontal gene transfer of weakly selected, functionally coupled genes. The majority of these are expected to be non-essential genes. From our analysis of the Escherichia coli genome, we conclude that the selfish operon hypothesis is unlikely to provide a general explanation for clustering nor can it account for the gene composition of operons. Contrary to expectations, essential genes with related functions have an especially strong tendency to cluster, even if they are not in operons. Moreover, essential genes are particularly abundant in operons.
Original languageEnglish
Pages (from-to)232-234
Number of pages3
JournalTrends in Genetics
Volume20
Issue number6
DOIs
Publication statusPublished - 2004

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Operon
Genes
Essential Genes
Cluster Analysis
Horizontal Gene Transfer
Genome
Escherichia coli

Cite this

Evidence against the selfish operon theory. / Pal, C; Hurst, L D.

In: Trends in Genetics, Vol. 20, No. 6, 2004, p. 232-234.

Research output: Contribution to journalArticle

Pal, C ; Hurst, L D. / Evidence against the selfish operon theory. In: Trends in Genetics. 2004 ; Vol. 20, No. 6. pp. 232-234.
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