Everybody needs good neighbours: the progressive DCIS microenvironment

Shayin V Gibson, Reza M Roozitalab, Michael D Allen, J Louise Jones, Edward P Carter, Richard P Grose

Research output: Contribution to journalReview articlepeer-review

5 Citations (SciVal)

Abstract

Ductal carcinoma in situ (DCIS) is a pre-invasive form of breast cancer where neoplastic luminal cells are confined to the ductal tree. While as many as 70% of DCIS cases will remain indolent, most women are treated with surgery, often combined with endocrine and radiotherapies. Overtreatment is therefore a major issue, demanding new methods to stratify patients. Somewhat paradoxically, the neoplastic cells in DCIS are genetically comparable to those in invasive disease, suggesting the tumour microenvironment is the driving force for progression. Clinical and mechanistic studies highlight the complex DCIS microenvironment, with multiple cell types competing to regulate progression. Here, we examine recent studies detailing distinct aspects of the DCIS microenvironment and discuss how these may inform more effective care.

Original languageEnglish
Pages (from-to)326-338
Number of pages13
JournalTrends in cancer
Volume9
Issue number4
Early online date2 Feb 2023
DOIs
Publication statusPublished - 1 Apr 2023

Keywords

  • Female
  • Humans
  • Carcinoma, Intraductal, Noninfiltrating/therapy
  • Tumor Microenvironment
  • Breast Neoplasms/genetics
  • ductal carcinoma in situ
  • invasion
  • biomarkers
  • breast cancer
  • tumour microenvironment

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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