Evaluation of feline leukemia virus control measures

S R Lubkin, J Romatowski, M Zhu, P M Kulesa, Katrin White

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

susceptible-infected-recovered-susceptible (SIRS) model of the epidemiology of feline leukemia virus is formulated and analysed. The dynamics of the disease are dramatically different in no-risk, low-risk and high-risk subpopulations of asocial, free roaming, and multiple cat household cats. Among low risk ( < 1% prevalence) free roaming cats, the model predicts than an effective immunization rate of 4% year−1, or an effective removal rate of 8% year−1are adequate to control the disease completely. Under higher risk (10% prevalence) conditions, an effective immunization rate of 23 –72% year−1or a removal rate of 60 –145% year−1are required for control. At very high (30%) prevalance rates, even heroic measures may not suffice to substantially reduce disease prevalance: a vaccination rate of 100% year−1even if attainable, would only slightly reduce disease prevalence from 30% to 29%. We conclude that the current estimated effective feline leukemia virus immunization rate of 11 –19% of the general population is inadequate to provide herd immunity in the subpopulation of cats which are genuinely at risk of infection. A substantial increase in the vaccination rate and/or intensification of test and removal efforts in the at risk population would be required to attain an effective level of protection.
Original languageEnglish
Pages (from-to)53-60
JournalJournal of Theoretical Biology
Volume178
Issue number1
DOIs
Publication statusPublished - 1996

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Feline Leukemia Virus
Feline leukemia virus
Leukemia
Viruses
Virus
control methods
Immunization
Evaluation
Cats
cats
immunization
Vaccination
vaccination
Herd Immunity
disease prevalence
Epidemiology
at-risk population
Immunity
epidemiology
households

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Evaluation of feline leukemia virus control measures. / Lubkin, S R; Romatowski, J; Zhu, M; Kulesa, P M ; White, Katrin.

In: Journal of Theoretical Biology, Vol. 178, No. 1, 1996, p. 53-60.

Research output: Contribution to journalArticle

Lubkin, S R ; Romatowski, J ; Zhu, M ; Kulesa, P M ; White, Katrin. / Evaluation of feline leukemia virus control measures. In: Journal of Theoretical Biology. 1996 ; Vol. 178, No. 1. pp. 53-60.
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