Evaluation of Eulerian and Lagrangian models for hemolysis estimation

M Ertan Taskin, Katharine H Fraser, Tao Zhang, Changfu Wu, Bartley P Griffith, Zhongjun J Wu

Research output: Contribution to journalArticlepeer-review

160 Citations (SciVal)


Hemolysis caused by flow-induced mechanical damage to red blood cells is still a problem in medical devices such as ventricular assist devices (VADs), artificial lungs, and mechanical heart valves. A number of different models have been proposed by different research groups for calculating the hemolysis, and of these, the power law–based models (HI(%)=Ctατβ) have proved the most popular because of their ease of use and applicability to a wide range of devices. However, within this power law category of models there are a number of different implementations. The aim of this work was to evaluate different power law–based models by calculating hemolysis in a specifically designed shearing device and a clinical VAD, and comparing the estimated results with experimental measurements of the hemolysis in these two devices. Both the Eulerian scalar transport and all the Lagrangian models had fairly large percentage of errors compared with the experiments (minimum Eulerian 91% and minimum Lagrangian 57%) showing they could not accurately predict the magnitude of the hemolysis. However, the Eulerian approach had large correlation coefficients (>0.99) showing that this method can predict relative hemolysis, which would be useful in comparative analysis, for example, for ranking different devices or for design optimization studies.
Original languageEnglish
Pages (from-to)363-372
Number of pages10
JournalAsaio Journal
Issue number4
Publication statusPublished - Jul 2012


Dive into the research topics of 'Evaluation of Eulerian and Lagrangian models for hemolysis estimation'. Together they form a unique fingerprint.

Cite this