Evaluation of allelic expression of imprinted genes in adult human blood

Jennifer M Frost; Dave Monk; Taita Stojilkovic-Mikic; Kathryn Woodfine; Lyn S Chitty; Adele Murrell; Philip Stanier; Gudrun E Moore

doi:10.1371/journal.pone.0013556

Evaluation of allelic expression of imprinted genes in adult human blood

Jennifer M Frost
, Dave Monk
, Taita Stojilkovic-Mikic
, Kathryn Woodfine
, Lyn S Chitty
, Adele Murrell
, Philip Stanier
, Gudrun E Moore

Department of Life Sciences

University College London

Research output: Contribution to journal › Article › peer-review

27 Citations (SciVal)

236 Downloads (Pure)

Abstract

Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.

Original language	English
Article number	e13556
Journal	PLoS ONE
Volume	5
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0013556
Publication status	Published - 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Alleles
Female
Genomic Imprinting
Humans
Male
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction

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10.1371/journal.pone.0013556

murrell_etal_plosone
2010 Frost et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 2.39 MBLicence: CC BY

Cite this

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AU - Chitty, Lyn S

AU - Murrell, Adele

AU - Stanier, Philip

AU - Moore, Gudrun E

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KW - Male

KW - Middle Aged

KW - Reverse Transcriptase Polymerase Chain Reaction

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ER -

Evaluation of allelic expression of imprinted genes in adult human blood

Abstract

UN SDGs

Keywords

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