Evaluation of allelic expression of imprinted genes in adult human blood

Jennifer M Frost; Dave Monk; Taita Stojilkovic-Mikic; Kathryn Woodfine; Lyn S Chitty; Adele Murrell; Philip Stanier; Gudrun E Moore

doi:10.1371/journal.pone.0013556

Evaluation of allelic expression of imprinted genes in adult human blood

Jennifer M Frost, Dave Monk, Taita Stojilkovic-Mikic, Kathryn Woodfine, Lyn S Chitty, Adele Murrell, Philip Stanier, Gudrun E Moore

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

25 Citations (SciVal)

151 Downloads (Pure)

Abstract

Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.

Original language	English
Article number	e13556
Journal	PLoS ONE
Volume	5
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0013556
Publication status	Published - 2010

Keywords

Adult
Alleles
Female
Genomic Imprinting
Humans
Male
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0013556

murrell_etal_plosone
2010 Frost et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 2.39 MBLicence: CC BY

Cite this

@article{bc63103fad754cfbb677072a33408d74,

title = "Evaluation of allelic expression of imprinted genes in adult human blood",

abstract = "Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.",

keywords = "Adult, Alleles, Female, Genomic Imprinting, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction",

author = "Frost, {Jennifer M} and Dave Monk and Taita Stojilkovic-Mikic and Kathryn Woodfine and Chitty, {Lyn S} and Adele Murrell and Philip Stanier and Moore, {Gudrun E}",

year = "2010",

doi = "10.1371/journal.pone.0013556",

language = "English",

volume = "5",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science (PLOS)",

number = "10",

}

TY - JOUR

T1 - Evaluation of allelic expression of imprinted genes in adult human blood

AU - Frost, Jennifer M

AU - Monk, Dave

AU - Stojilkovic-Mikic, Taita

AU - Woodfine, Kathryn

AU - Chitty, Lyn S

AU - Murrell, Adele

AU - Stanier, Philip

AU - Moore, Gudrun E

PY - 2010

Y1 - 2010

N2 - Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.

AB - Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.

KW - Adult

KW - Alleles

KW - Female

KW - Genomic Imprinting

KW - Humans

KW - Male

KW - Middle Aged

KW - Reverse Transcriptase Polymerase Chain Reaction

UR - http://dx.doi.org/10.1371/journal.pone.0013556

U2 - 10.1371/journal.pone.0013556

DO - 10.1371/journal.pone.0013556

M3 - Article

C2 - 21042416

SN - 1932-6203

VL - 5

JO - PLoS ONE

JF - PLoS ONE

IS - 10

M1 - e13556

ER -

Evaluation of allelic expression of imprinted genes in adult human blood

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this