Evaluation of allelic expression of imprinted genes in adult human blood

Jennifer M Frost, Dave Monk, Taita Stojilkovic-Mikic, Kathryn Woodfine, Lyn S Chitty, Adele Murrell, Philip Stanier, Gudrun E Moore

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
125 Downloads (Pure)

Abstract

Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults.
Original languageEnglish
Article numbere13556
JournalPLoS ONE
Volume5
Issue number10
DOIs
Publication statusPublished - 2010

Keywords

  • Adult
  • Alleles
  • Female
  • Genomic Imprinting
  • Humans
  • Male
  • Middle Aged
  • Reverse Transcriptase Polymerase Chain Reaction

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