Projects per year
Abstract
Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.
Original language | English |
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Pages (from-to) | 1582-1588 |
Number of pages | 7 |
Journal | Science of the Total Environment |
Volume | 609 |
Early online date | 8 Aug 2017 |
DOIs | |
Publication status | Published - 31 Dec 2017 |
Keywords
- 1,7-dimethyluric acid
- Back-calculation
- Caffeine
- Correction factor
- Urinary biomarkers
- Wastewater-based epidemiology
ASJC Scopus subject areas
- Environmental Engineering
- Environmental Chemistry
- Waste Management and Disposal
- Pollution
Fingerprint
Dive into the research topics of 'Estimation of caffeine intake from analysis of caffeine metabolites in wastewater'. Together they form a unique fingerprint.Projects
- 1 Finished
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Marie Curie ITN - SEWPROF A New Paradigm in Drug Use and Human Health Risk Assessment: Sewage Profiling at the Community Level management
Kasprzyk-Hordern, B. (PI), Estrela, P. (CoI) & Frost, C. (CoI)
1/10/12 → 30/09/16
Project: EU Commission
Equipment
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MC2-Mass Spectrometry (MS)
Material and Chemical Characterisation (MC2)Facility/equipment: Technology type