Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

Emma  Gracia-Lor; Nikolaos I. Rousis; Ettore Zuccato; Richard Bade; Jose Antonio Baz Lomba; Erika Castrignanò; Ana Causanilles; Félix Hernández; Barbara Kasprzyk-Hordern; Juliet Kinyua; Ann Kathrin McCall; Alexander L.N. van Nuijs; Benedek G. Plósz; Pedram Ramin; Yeonsuk Ryu; Miguel A. Santos; Kevin Thomas; Pim de Voogt; Zhugen Yang; Sara Castiglioni

doi:10.1016/j.scitotenv.2017.07.258

Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

Emma Gracia-Lor, Nikolaos I. Rousis, Ettore Zuccato, Richard Bade, Jose Antonio Baz Lomba, Erika Castrignanò, Ana Causanilles, Félix Hernández, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann Kathrin McCall, Alexander L.N. van Nuijs, Benedek G. Plósz, Pedram Ramin, Yeonsuk Ryu, Miguel A. Santos, Kevin Thomas, Pim de Voogt, Zhugen Yang, Sara Castiglioni

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Abstract

Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.

Original language	English
Pages (from-to)	1582-1588
Number of pages	7
Journal	Science of the Total Environment
Volume	609
Early online date	8 Aug 2017
DOIs	https://doi.org/10.1016/j.scitotenv.2017.07.258
Publication status	Published - 31 Dec 2017

Keywords

1,7-dimethyluric acid
Back-calculation
Caffeine
Correction factor
Urinary biomarkers
Wastewater-based epidemiology

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

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10.1016/j.scitotenv.2017.07.258

Caffeine _Manuscript_NO changes markedAccepted author manuscript, 695 KBLicence: CC BY-NC-ND

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Gracia-Lor, E., Rousis, N. I., Zuccato, E., Bade, R., Baz Lomba, J. A., Castrignanò, E., Causanilles, A., Hernández, F., Kasprzyk-Hordern, B., Kinyua, J., McCall, A. K., van Nuijs, A. L. N., Plósz, B. G., Ramin, P., Ryu, Y., Santos, M. A., Thomas, K., de Voogt, P., Yang, Z., & Castiglioni, S. (2017). Estimation of caffeine intake from analysis of caffeine metabolites in wastewater. Science of the Total Environment, 609, 1582-1588. https://doi.org/10.1016/j.scitotenv.2017.07.258

Gracia-Lor, E, Rousis, NI, Zuccato, E, Bade, R, Baz Lomba, JA, Castrignanò, E, Causanilles, A, Hernández, F, Kasprzyk-Hordern, B, Kinyua, J, McCall, AK, van Nuijs, ALN, Plósz, BG, Ramin, P, Ryu, Y, Santos, MA, Thomas, K, de Voogt, P, Yang, Z & Castiglioni, S 2017, 'Estimation of caffeine intake from analysis of caffeine metabolites in wastewater', Science of the Total Environment, vol. 609, pp. 1582-1588. https://doi.org/10.1016/j.scitotenv.2017.07.258

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abstract = "Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.",

keywords = "1,7-dimethyluric acid, Back-calculation, Caffeine, Correction factor, Urinary biomarkers, Wastewater-based epidemiology",

author = "Emma Gracia-Lor and Rousis, {Nikolaos I.} and Ettore Zuccato and Richard Bade and {Baz Lomba}, {Jose Antonio} and Erika Castrignan{\`o} and Ana Causanilles and F{\'e}lix Hern{\'a}ndez and Barbara Kasprzyk-Hordern and Juliet Kinyua and McCall, {Ann Kathrin} and {van Nuijs}, {Alexander L.N.} and Pl{\'o}sz, {Benedek G.} and Pedram Ramin and Yeonsuk Ryu and Santos, {Miguel A.} and Kevin Thomas and {de Voogt}, Pim and Zhugen Yang and Sara Castiglioni",

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doi = "10.1016/j.scitotenv.2017.07.258",

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AU - Gracia-Lor, Emma

AU - Rousis, Nikolaos I.

AU - Zuccato, Ettore

AU - Bade, Richard

AU - Baz Lomba, Jose Antonio

AU - Castrignanò, Erika

AU - Causanilles, Ana

AU - Hernández, Félix

AU - Kasprzyk-Hordern, Barbara

AU - Kinyua, Juliet

AU - McCall, Ann Kathrin

AU - van Nuijs, Alexander L.N.

AU - Plósz, Benedek G.

AU - Ramin, Pedram

AU - Ryu, Yeonsuk

AU - Santos, Miguel A.

AU - Thomas, Kevin

AU - de Voogt, Pim

AU - Yang, Zhugen

AU - Castiglioni, Sara

PY - 2017/12/31

Y1 - 2017/12/31

N2 - Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.

AB - Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use.

KW - 1,7-dimethyluric acid

KW - Back-calculation

KW - Caffeine

KW - Correction factor

KW - Urinary biomarkers

KW - Wastewater-based epidemiology

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ER -

Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

Abstract

Keywords

ASJC Scopus subject areas

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Marie Curie ITN - SEWPROF A New Paradigm in Drug Use and Human Health Risk Assessment: Sewage Profiling at the Community Level management

MC2-Mass Spectrometry (MS)

Cite this

Estimation of caffeine intake from analysis of caffeine metabolites in wastewater

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Marie Curie ITN - SEWPROF A New Paradigm in Drug Use and Human Health Risk Assessment: Sewage Profiling at the Community Level management

Equipment

MC2-Mass Spectrometry (MS)

Cite this