ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND' biological thiols

Luling Wu; Hai Hao Han; Liyuan Liu; Jordan E. Gardiner; Adam C. Sedgwick; Chusen Huang; Steven D. Bull; Xiao Peng He; Tony D. James

doi:10.1039/c8cc06917d

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND' biological thiols

Luling Wu, Hai Hao Han, Liyuan Liu, Jordan E. Gardiner, Adam C. Sedgwick, Chusen Huang, Steven D. Bull, Xiao Peng He, Tony D. James

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

65 Citations (SciVal)

Abstract

An ESIPT-based ‘AND' logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO⁻ and biological thiols. GSH-ABAH was shown to have good cell permeability and with the addition of just SIN-1 (ONOO⁻ donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO⁻ ‘AND' GSH added to RAW264.7 cells.

Original language	English
Pages (from-to)	11336-11339
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	80
Early online date	11 Sept 2018
DOIs	https://doi.org/10.1039/c8cc06917d
Publication status	Published - 14 Oct 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "ESIPT-based fluorescence probe for the rapid detection of peroxynitrite {\textquoteleft}AND' biological thiols",

abstract = "An ESIPT-based {\textquoteleft}AND' logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO− and biological thiols. GSH-ABAH was shown to have good cell permeability and with the addition of just SIN-1 (ONOO− donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO− {\textquoteleft}AND' GSH added to RAW264.7 cells.",

author = "Luling Wu and Han, {Hai Hao} and Liyuan Liu and Gardiner, {Jordan E.} and Sedgwick, {Adam C.} and Chusen Huang and Bull, {Steven D.} and He, {Xiao Peng} and James, {Tony D.}",

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doi = "10.1039/c8cc06917d",

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AU - Wu, Luling

AU - Han, Hai Hao

AU - Liu, Liyuan

AU - Gardiner, Jordan E.

AU - Sedgwick, Adam C.

AU - Huang, Chusen

AU - Bull, Steven D.

AU - He, Xiao Peng

AU - James, Tony D.

PY - 2018/10/14

Y1 - 2018/10/14

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AB - An ESIPT-based ‘AND' logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO− and biological thiols. GSH-ABAH was shown to have good cell permeability and with the addition of just SIN-1 (ONOO− donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO− ‘AND' GSH added to RAW264.7 cells.

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JO - Chemical Communications

JF - Chemical Communications

IS - 80

ER -

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND' biological thiols

Abstract

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