ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND' biological thiols

Luling Wu, Hai Hao Han, Liyuan Liu, Jordan E. Gardiner, Adam C. Sedgwick, Chusen Huang, Steven D. Bull, Xiao Peng He, Tony D. James

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

An ESIPT-based ‘AND' logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO and biological thiols. GSH-ABAH was shown to have good cell permeability and with the addition of just SIN-1 (ONOO donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO ‘AND' GSH added to RAW264.7 cells.

Original languageEnglish
Pages (from-to)11336-11339
Number of pages4
JournalChemical Communications
Volume54
Issue number80
Early online date11 Sep 2018
DOIs
Publication statusPublished - 14 Oct 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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