Error prevention and mitigation as forces in the evolution of genes and genomes

Tobias Warnecke; Laurence D Hurst

doi:10.1038/nrg3092

Error prevention and mitigation as forces in the evolution of genes and genomes

Tobias Warnecke, Laurence D Hurst

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Abstract

Why are short introns rarely a multiple of three nucleotides long? Why do essential genes cluster? Why are genes in operons often lined up in the order in which they are needed in the encoded pathway? In this Opinion article, we argue that these and many other - ostensibly disparate - observations are all pieces of an emerging picture in which multiple aspects of gene anatomy and genome architecture have evolved in response to error-prone gene expression.

Original language	English
Pages (from-to)	875-881
Number of pages	7
Journal	Nature Reviews Genetics
Volume	12
Issue number	12
DOIs	https://doi.org/10.1038/nrg3092
Publication status	Published - Dec 2011

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Error prevention and mitigation as forces in the evolution of genes and genomes

Abstract

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