Abstract
Solar UVA irradiation-generated reactive oxygen species (ROS) induces the expression of matrix metalloproteinase 1 (MMP-1), leading to photoaging, however the molecular mechanism remains unclear. In the present study, we found that eriodictyol remarkably reduces UVA-mediated ROS generation and protects the skin cells from oxidative damage and the ensuing cell death. Moreover eriodictyol pretreatment significantly down-regulates the UVA-induced MMP-1 expression, and lowers the inflammatory responses within the skin cells. Pretreatment with eriodictyol upregulates the expression of tissue inhibitory metalloproteinase 1 (TIMP-1) and collagen-I (COL-1) at the transcriptional level in a dose-dependent manner. UVA-induced phosphorylation levels of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 leading to increased MMP-1 expression are significantly reduced in eriodictyol-treated skin cells. In addition, eriodictyol pretreatment significantly suppresses inflammatory cytokines and inhibits the activation of MAPK signaling cascades in skin cells. Taken together, our results demonstrate that eriodictyol has both potent anti-inflammatory and anti-photoaging effects.
Original language | English |
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Article number | 112350 |
Journal | Journal of Photochemistry and Photobiology B: Biology |
Volume | 226 |
Early online date | 30 Oct 2021 |
DOIs | |
Publication status | Published - 31 Jan 2022 |
Funding
This work is financially supported by The National Science Foundation of China (Nos. 81704091, 81271776, 81573073). Series of Evidence Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (To JL Zhong). The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG003). Key projects of Chongqing Municipal Science and Technology Commission (cstc2017jcyjbx0044). China Postdoctoral Science Foundation (Grant No. 2019M653348). Natural Science Foundation of Chongqing, China, (cstc2019jcyj-msxmX0757). Moreover, this work has also been supported by Science and Health Joint medical research project in Chongqing Wanzhou District (wzstc-kw2020007).
Keywords
- Anti-photoaging
- COL-1
- Eriodictyol
- MAPK
- MMP-1
- ROS
- TIMP-1
- UVA
ASJC Scopus subject areas
- Radiation
- Radiological and Ultrasound Technology
- Biophysics
- Radiology Nuclear Medicine and imaging