@article{1612478f3c644bf4a1308d7ea701250a,
title = "Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway",
abstract = "Solar UVA irradiation-generated reactive oxygen species (ROS) induces the expression of matrix metalloproteinase 1 (MMP-1), leading to photoaging, however the molecular mechanism remains unclear. In the present study, we found that eriodictyol remarkably reduces UVA-mediated ROS generation and protects the skin cells from oxidative damage and the ensuing cell death. Moreover eriodictyol pretreatment significantly down-regulates the UVA-induced MMP-1 expression, and lowers the inflammatory responses within the skin cells. Pretreatment with eriodictyol upregulates the expression of tissue inhibitory metalloproteinase 1 (TIMP-1) and collagen-I (COL-1) at the transcriptional level in a dose-dependent manner. UVA-induced phosphorylation levels of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 leading to increased MMP-1 expression are significantly reduced in eriodictyol-treated skin cells. In addition, eriodictyol pretreatment significantly suppresses inflammatory cytokines and inhibits the activation of MAPK signaling cascades in skin cells. Taken together, our results demonstrate that eriodictyol has both potent anti-inflammatory and anti-photoaging effects.",
keywords = "Anti-photoaging, COL-1, Eriodictyol, MAPK, MMP-1, ROS, TIMP-1, UVA",
author = "Nisar, {Muhammad Farrukh} and Tiantian Liu and Mei Wang and Shida Chen and Li Chang and Karisma, {Vega Widya} and Weixu and Qingchun Diao and Mei Xue and Xueyong Tang and Charareh Pourzand and Jing Yang and Zhong, {J L}",
note = "Funding Information: This work is financially supported by The National Science Foundation of China (Nos. 81704091, 81271776, 81573073). Series of Evidence Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (To JL Zhong). The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG003). Key projects of Chongqing Municipal Science and Technology Commission (cstc2017jcyjbx0044). China Postdoctoral Science Foundation (Grant No. 2019M653348). Natural Science Foundation of Chongqing, China, (cstc2019jcyj-msxmX0757). Moreover, this work has also been supported by Science and Health Joint medical research project in Chongqing Wanzhou District (wzstc-kw2020007). Funding Information: This work is financially supported by The National Science Foundation of China (Nos. 81704091 , 81271776 , 81573073 ). Series of Evidence Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (To JL Zhong). The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG003 ). Key projects of Chongqing Municipal Science and Technology Commission ( cstc2017jcyjbx0044 ). China Postdoctoral Science Foundation (Grant No. 2019M653348 ). Natural Science Foundation of Chongqing, China , ( cstc2019jcyj-msxmX0757 ). Moreover, this work has also been supported by Science and Health Joint medical research project in Chongqing Wanzhou District ( wzstc-kw2020007 ). ",
year = "2022",
month = jan,
day = "31",
doi = "10.1016/j.jphotobiol.2021.112350",
language = "English",
volume = "226",
journal = "Journal of Photochemistry and Photobiology B: Biology",
issn = "1011-1344",
publisher = "Elsevier",
}