Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway

Muhammad Farrukh Nisar, Tiantian Liu, Mei Wang, Shida Chen, Li Chang, Vega Widya Karisma, Weixu, Qingchun Diao, Mei Xue, Xueyong Tang, Charareh Pourzand, Jing Yang, J L Zhong

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Abstract

Solar UVA irradiation-generated reactive oxygen species (ROS) induces the expression of matrix metalloproteinase 1 (MMP-1), leading to photoaging, however the molecular mechanism remains unclear. In the present study, we found that eriodictyol remarkably reduces UVA-mediated ROS generation and protects the skin cells from oxidative damage and the ensuing cell death. Moreover eriodictyol pretreatment significantly down-regulates the UVA-induced MMP-1 expression, and lowers the inflammatory responses within the skin cells. Pretreatment with eriodictyol upregulates the expression of tissue inhibitory metalloproteinase 1 (TIMP-1) and collagen-I (COL-1) at the transcriptional level in a dose-dependent manner. UVA-induced phosphorylation levels of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 leading to increased MMP-1 expression are significantly reduced in eriodictyol-treated skin cells. In addition, eriodictyol pretreatment significantly suppresses inflammatory cytokines and inhibits the activation of MAPK signaling cascades in skin cells. Taken together, our results demonstrate that eriodictyol has both potent anti-inflammatory and anti-photoaging effects.

Original languageEnglish
Article number112350
JournalJournal of Photochemistry and Photobiology B: Biology
Volume226
Early online date30 Oct 2021
DOIs
Publication statusPublished - 31 Jan 2022

Bibliographical note

Funding Information:
This work is financially supported by The National Science Foundation of China (Nos. 81704091, 81271776, 81573073). Series of Evidence Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (To JL Zhong). The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG003). Key projects of Chongqing Municipal Science and Technology Commission (cstc2017jcyjbx0044). China Postdoctoral Science Foundation (Grant No. 2019M653348). Natural Science Foundation of Chongqing, China, (cstc2019jcyj-msxmX0757). Moreover, this work has also been supported by Science and Health Joint medical research project in Chongqing Wanzhou District (wzstc-kw2020007).

Funding Information:
This work is financially supported by The National Science Foundation of China (Nos. 81704091 , 81271776 , 81573073 ). Series of Evidence Based Study on Hot Spring Wellness, Chongqing Municipal Commission of Culture and Tourism Development (To JL Zhong). The Fundamental Research Funds for the Central Universities (Project No. 2020CDJYGSG003 ). Key projects of Chongqing Municipal Science and Technology Commission ( cstc2017jcyjbx0044 ). China Postdoctoral Science Foundation (Grant No. 2019M653348 ). Natural Science Foundation of Chongqing, China , ( cstc2019jcyj-msxmX0757 ). Moreover, this work has also been supported by Science and Health Joint medical research project in Chongqing Wanzhou District ( wzstc-kw2020007 ).

Keywords

  • Anti-photoaging
  • COL-1
  • Eriodictyol
  • MAPK
  • MMP-1
  • ROS
  • TIMP-1
  • UVA

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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