Epoxidation of styrene and substituted styrenes by whole cells of mycobacterium sp. M156

Stuart R. Rigby; Colette S. Matthews; David J. Leak

doi:10.1016/0968-0896(94)80026-X

Epoxidation of styrene and substituted styrenes by whole cells of mycobacterium sp. M156

Stuart R. Rigby, Colette S. Matthews, David J. Leak

Research output: Contribution to journal › Article › peer-review

Abstract

Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. α-Methylstyrene was also epoxidised at a lower rate, while trans-β-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.

Original language	English
Pages (from-to)	553-556
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/0968-0896(94)80026-X
Publication status	Published - 1 Jan 1994

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Epoxidation of styrene and substituted styrenes by whole cells of mycobacterium sp. M156",

abstract = "Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. α-Methylstyrene was also epoxidised at a lower rate, while trans-β-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.",

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AU - Rigby, Stuart R.

AU - Matthews, Colette S.

AU - Leak, David J.

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Y1 - 1994/1/1

N2 - Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. α-Methylstyrene was also epoxidised at a lower rate, while trans-β-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.

AB - Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. α-Methylstyrene was also epoxidised at a lower rate, while trans-β-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.

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ER -

Epoxidation of styrene and substituted styrenes by whole cells of mycobacterium sp. M156

Abstract

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