Epoxidation of styrene and substituted styrenes by whole cells of mycobacterium sp. M156

Stuart R. Rigby, Colette S. Matthews, David J. Leak

Research output: Contribution to journalArticle

Abstract

Whole cells of the propene utilizing Mycobacterium sp. M156 (NCIMB 40156) oxidised styrene, 2-,3- and 4-fluorostyrene, 3- and 4-chlorostyrene and 3- and 4-methylstyrenes to their respective epoxides. Rates of oxidation were comparable to that of styrene. α-Methylstyrene was also epoxidised at a lower rate, while trans-β-methylstyrene and 1,2-dihydronaphthalene were poor substrates. In those cases that were investigated, epoxidation occurred with a high degree of stereospecificity.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume2
Issue number6
DOIs
Publication statusPublished - 1 Jan 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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