Epithelial metaplasia and the development of cancer

J M Quinlan, B J Colleypriest, M Farrant, D Tosh

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Metaplasia means the conversion, in postnatal life, of one cell type to another. Understanding the steps leading to metaplasia is important for two reasons. Firstly, it tells us something about the normal developmental biology of the tissues that interconvert. Secondly, metaplasia predisposes to certain forms of neoplasia. So understanding the molecular and cellular mechanisms underlying metaplasia will provide insights into clinical diagnosis and potential therapies. One of the best-described examples of metaplasia is Barrett's metaplasia or the appearance of intestinal-like columnar tissue in the oesophagus. Barrett's metaplasia develops as a result of gastro-oesophageal reflux and is considered the precursor lesion for oesophageal adenocarcinoma. While we know quite a bit about the molecular events associated with the development of oesophageal adenocarcinoma, our understanding of the initial events leading to Barrett's metaplasia is lacking. In the present review we will focus on examples of metaplasia that lead to neoplasia and discuss some of the underlying molecular and cellular mechanisms. (c) 2007 Elsevier B.V All rights reserved.
Original languageEnglish
Pages (from-to)10-21
Number of pages12
JournalBiochimica Et Biophysica Acta-Reviews on Cancer
Volume1776
Issue number1
DOIs
Publication statusPublished - 2007

Fingerprint

Metaplasia
Barrett Esophagus
Neoplasms
Adenocarcinoma
Developmental Biology
Gastroesophageal Reflux
Esophagus

Cite this

Epithelial metaplasia and the development of cancer. / Quinlan, J M; Colleypriest, B J; Farrant, M; Tosh, D.

In: Biochimica Et Biophysica Acta-Reviews on Cancer, Vol. 1776, No. 1, 2007, p. 10-21.

Research output: Contribution to journalArticle

Quinlan, J M ; Colleypriest, B J ; Farrant, M ; Tosh, D. / Epithelial metaplasia and the development of cancer. In: Biochimica Et Biophysica Acta-Reviews on Cancer. 2007 ; Vol. 1776, No. 1. pp. 10-21.
@article{1297cd3443154cf4bc5cfafd21c03e82,
title = "Epithelial metaplasia and the development of cancer",
abstract = "Metaplasia means the conversion, in postnatal life, of one cell type to another. Understanding the steps leading to metaplasia is important for two reasons. Firstly, it tells us something about the normal developmental biology of the tissues that interconvert. Secondly, metaplasia predisposes to certain forms of neoplasia. So understanding the molecular and cellular mechanisms underlying metaplasia will provide insights into clinical diagnosis and potential therapies. One of the best-described examples of metaplasia is Barrett's metaplasia or the appearance of intestinal-like columnar tissue in the oesophagus. Barrett's metaplasia develops as a result of gastro-oesophageal reflux and is considered the precursor lesion for oesophageal adenocarcinoma. While we know quite a bit about the molecular events associated with the development of oesophageal adenocarcinoma, our understanding of the initial events leading to Barrett's metaplasia is lacking. In the present review we will focus on examples of metaplasia that lead to neoplasia and discuss some of the underlying molecular and cellular mechanisms. (c) 2007 Elsevier B.V All rights reserved.",
author = "Quinlan, {J M} and Colleypriest, {B J} and M Farrant and D Tosh",
year = "2007",
doi = "10.1016/j.bbcan.2007.05.005",
language = "English",
volume = "1776",
pages = "10--21",
journal = "Biochimica Et Biophysica Acta-Reviews on Cancer",
issn = "0304-419X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Epithelial metaplasia and the development of cancer

AU - Quinlan, J M

AU - Colleypriest, B J

AU - Farrant, M

AU - Tosh, D

PY - 2007

Y1 - 2007

N2 - Metaplasia means the conversion, in postnatal life, of one cell type to another. Understanding the steps leading to metaplasia is important for two reasons. Firstly, it tells us something about the normal developmental biology of the tissues that interconvert. Secondly, metaplasia predisposes to certain forms of neoplasia. So understanding the molecular and cellular mechanisms underlying metaplasia will provide insights into clinical diagnosis and potential therapies. One of the best-described examples of metaplasia is Barrett's metaplasia or the appearance of intestinal-like columnar tissue in the oesophagus. Barrett's metaplasia develops as a result of gastro-oesophageal reflux and is considered the precursor lesion for oesophageal adenocarcinoma. While we know quite a bit about the molecular events associated with the development of oesophageal adenocarcinoma, our understanding of the initial events leading to Barrett's metaplasia is lacking. In the present review we will focus on examples of metaplasia that lead to neoplasia and discuss some of the underlying molecular and cellular mechanisms. (c) 2007 Elsevier B.V All rights reserved.

AB - Metaplasia means the conversion, in postnatal life, of one cell type to another. Understanding the steps leading to metaplasia is important for two reasons. Firstly, it tells us something about the normal developmental biology of the tissues that interconvert. Secondly, metaplasia predisposes to certain forms of neoplasia. So understanding the molecular and cellular mechanisms underlying metaplasia will provide insights into clinical diagnosis and potential therapies. One of the best-described examples of metaplasia is Barrett's metaplasia or the appearance of intestinal-like columnar tissue in the oesophagus. Barrett's metaplasia develops as a result of gastro-oesophageal reflux and is considered the precursor lesion for oesophageal adenocarcinoma. While we know quite a bit about the molecular events associated with the development of oesophageal adenocarcinoma, our understanding of the initial events leading to Barrett's metaplasia is lacking. In the present review we will focus on examples of metaplasia that lead to neoplasia and discuss some of the underlying molecular and cellular mechanisms. (c) 2007 Elsevier B.V All rights reserved.

UR - http://dx.doi.org/10.1016/j.bbcan.2007.05.005

U2 - 10.1016/j.bbcan.2007.05.005

DO - 10.1016/j.bbcan.2007.05.005

M3 - Article

VL - 1776

SP - 10

EP - 21

JO - Biochimica Et Biophysica Acta-Reviews on Cancer

JF - Biochimica Et Biophysica Acta-Reviews on Cancer

SN - 0304-419X

IS - 1

ER -