Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message

Giuseppina Pisignano, Michael Ladomery

Research output: Contribution to journalReview articlepeer-review

20 Citations (SciVal)


Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type-and tissue-specific manner, and defects in alternative splicing can dramatically alter RNA and protein functions and lead to disease. The eukaryotic genome is also intensively transcribed into long and short non-coding RNAs which account for up to 90% of the entire tran-scriptome. Over the years, lncRNAs have received considerable attention as important players in the regulation of cellular processes including alternative splicing. In this review, we focus on recent discoveries that show how lncRNAs contribute significantly to the regulation of alternative splicing and explore how they are able to shape the expression of a diverse set of splice isoforms through several mechanisms. With the increasing number of lncRNAs being discovered and characterized, the contribution of lncRNAs to the regulation of alternative splicing is likely to grow significantly.

Original languageEnglish
Article number21
JournalNon-coding RNA
Issue number1
Publication statusPublished - 11 Mar 2021


  • Alternative splicing
  • Long non-coding RNAs
  • Post-transcriptional regulation
  • Splicing factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message'. Together they form a unique fingerprint.

Cite this