Enzymatic hydrolysis and selective racemisation reactions of alpha-chloro esters

L Haughton; J M J Williams

Enzymatic hydrolysis and selective racemisation reactions of alpha-chloro esters

L Haughton, J M J Williams

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The kinetic resolution of a-chloro esters was effected with good selectivity using CLEC (Cross-Linked Enzyme Crystals) enzymes. The selective racemisation of a-chloro esters in the presence of alpha -chloro acids enabled a successful dynamic kinetic resolution reaction to be performed.

Original language	English
Pages (from-to)	943-946
Number of pages	4
Journal	Synthesis
Issue number	6
Publication status	Published - 2001

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title = "Enzymatic hydrolysis and selective racemisation reactions of alpha-chloro esters",

abstract = "The kinetic resolution of a-chloro esters was effected with good selectivity using CLEC (Cross-Linked Enzyme Crystals) enzymes. The selective racemisation of a-chloro esters in the presence of alpha -chloro acids enabled a successful dynamic kinetic resolution reaction to be performed.",

author = "L Haughton and Williams, {J M J}",

note = "ID number: ISI:000168626000025",

year = "2001",

language = "English",

pages = "943--946",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "6",

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TY - JOUR

T1 - Enzymatic hydrolysis and selective racemisation reactions of alpha-chloro esters

AU - Haughton, L

AU - Williams, J M J

N1 - ID number: ISI:000168626000025

PY - 2001

Y1 - 2001

N2 - The kinetic resolution of a-chloro esters was effected with good selectivity using CLEC (Cross-Linked Enzyme Crystals) enzymes. The selective racemisation of a-chloro esters in the presence of alpha -chloro acids enabled a successful dynamic kinetic resolution reaction to be performed.

AB - The kinetic resolution of a-chloro esters was effected with good selectivity using CLEC (Cross-Linked Enzyme Crystals) enzymes. The selective racemisation of a-chloro esters in the presence of alpha -chloro acids enabled a successful dynamic kinetic resolution reaction to be performed.

M3 - Article

SP - 943

EP - 946

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 6

ER -