Enhanced Protein Separation Performance of Cellulose Acetate Membranes Modified with Covalent Organic Frameworks

Shurui Shao; Maoyu Liu; Baifu Tao; Kayode Hassan Lasisi; Wenqiao Meng; Xing Wu; Kaisong Zhang

doi:10.3390/membranes15030084

Enhanced Protein Separation Performance of Cellulose Acetate Membranes Modified with Covalent Organic Frameworks

Shurui Shao, Maoyu Liu, Baifu Tao, Kayode Hassan Lasisi, Wenqiao Meng, Xing Wu, Kaisong Zhang

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (SciVal)

Abstract

As a porous crystalline material, covalent organic frameworks (COFs) have attracted significant attention due to their extraordinary features, such as an ordered pore structure and excellent stability. Synthesized through the aldehyde amine condensation reaction, TpPa-1 COFs (Triformylphloroglucinol-p-Phenylenediamine-1 COFs) were blended with cellulose acetate (CA) to form a casting solution. The TpPa-1 COF/CA ultrafiltration membrane was then prepared using the non-solvent-induced phase inversion (NIPS) method. The influence of TpPa-1 COFs content on the hydrophilicity, stability and filtration performance of the modified membrane was studied. Due to the hydrophilic groups in TpPa-1 COFs and the network structure formed by covalent bonds, the modified CA membranes exhibited higher hydrophilicity and lower protein adsorption compared with the pristine CA membrane. The porous crystalline structure of TpPa-1 COFs increased the water permeation path in the CA membrane, improving the permeability of the modified membrane while maintaining an outstanding bovine serum albumin (BSA) rejection. Furthermore, the addition of TpPa-1 COFs reduced protein adsorption on the CA membrane and overcame the trade-off between permeability and selectivity in CA membrane bioseparation applications. This approach provides a sustainable method for enhancing membrane performance while enhancing the application of membranes in protein purification.

Original language	English
Article number	84
Number of pages	18
Journal	Membranes
Volume	15
Issue number	3
Early online date	6 Mar 2025
DOIs	https://doi.org/10.3390/membranes15030084
Publication status	Published - 6 Mar 2025

Data Availability Statement

The original contributions presented in this study are included in the
article. Further inquiries can be directed to the corresponding author(s).

Funding

This work was supported by grants from the National Key R&D Program of China (2023YFC3700038), the Ministry of Science and Technology. K.S. Zhang thanks the Ocean University of China for providing the Zhufeng Distinguished Professor Fellowship.

Keywords

cellulose acetate
covalent organic frameworks
protein adsorption
trade-off
ultrafiltration

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Process Chemistry and Technology
Filtration and Separation

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10.3390/membranes15030084Licence: CC BY

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title = "Enhanced Protein Separation Performance of Cellulose Acetate Membranes Modified with Covalent Organic Frameworks",

abstract = "As a porous crystalline material, covalent organic frameworks (COFs) have attracted significant attention due to their extraordinary features, such as an ordered pore structure and excellent stability. Synthesized through the aldehyde amine condensation reaction, TpPa-1 COFs (Triformylphloroglucinol-p-Phenylenediamine-1 COFs) were blended with cellulose acetate (CA) to form a casting solution. The TpPa-1 COF/CA ultrafiltration membrane was then prepared using the non-solvent-induced phase inversion (NIPS) method. The influence of TpPa-1 COFs content on the hydrophilicity, stability and filtration performance of the modified membrane was studied. Due to the hydrophilic groups in TpPa-1 COFs and the network structure formed by covalent bonds, the modified CA membranes exhibited higher hydrophilicity and lower protein adsorption compared with the pristine CA membrane. The porous crystalline structure of TpPa-1 COFs increased the water permeation path in the CA membrane, improving the permeability of the modified membrane while maintaining an outstanding bovine serum albumin (BSA) rejection. Furthermore, the addition of TpPa-1 COFs reduced protein adsorption on the CA membrane and overcame the trade-off between permeability and selectivity in CA membrane bioseparation applications. This approach provides a sustainable method for enhancing membrane performance while enhancing the application of membranes in protein purification.",

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AU - Shao, Shurui

AU - Liu, Maoyu

AU - Tao, Baifu

AU - Lasisi, Kayode Hassan

AU - Meng, Wenqiao

AU - Wu, Xing

AU - Zhang, Kaisong

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AB - As a porous crystalline material, covalent organic frameworks (COFs) have attracted significant attention due to their extraordinary features, such as an ordered pore structure and excellent stability. Synthesized through the aldehyde amine condensation reaction, TpPa-1 COFs (Triformylphloroglucinol-p-Phenylenediamine-1 COFs) were blended with cellulose acetate (CA) to form a casting solution. The TpPa-1 COF/CA ultrafiltration membrane was then prepared using the non-solvent-induced phase inversion (NIPS) method. The influence of TpPa-1 COFs content on the hydrophilicity, stability and filtration performance of the modified membrane was studied. Due to the hydrophilic groups in TpPa-1 COFs and the network structure formed by covalent bonds, the modified CA membranes exhibited higher hydrophilicity and lower protein adsorption compared with the pristine CA membrane. The porous crystalline structure of TpPa-1 COFs increased the water permeation path in the CA membrane, improving the permeability of the modified membrane while maintaining an outstanding bovine serum albumin (BSA) rejection. Furthermore, the addition of TpPa-1 COFs reduced protein adsorption on the CA membrane and overcame the trade-off between permeability and selectivity in CA membrane bioseparation applications. This approach provides a sustainable method for enhancing membrane performance while enhancing the application of membranes in protein purification.

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KW - protein adsorption

KW - trade-off

KW - ultrafiltration

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Enhanced Protein Separation Performance of Cellulose Acetate Membranes Modified with Covalent Organic Frameworks

Abstract

Data Availability Statement

Funding

Keywords

ASJC Scopus subject areas

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