Enhanced hemocompatibility of a PEGilated polycarbonate based segmented polyurethane

Helma Vakili; Mohsen Mohseni; Hossein Ghanbari; Hossein Yahyaei; Hesam Makki; Alba González; Ana Alonso-Varona; Patricia Garrido Pascual; Lourdes Irusta

doi:10.1080/00914037.2020.1857760

Enhanced hemocompatibility of a PEGilated polycarbonate based segmented polyurethane

Helma Vakili, Mohsen Mohseni, Hossein Ghanbari, Hossein Yahyaei, Hesam Makki, Alba González, Ana Alonso-Varona, Patricia Garrido Pascual, Lourdes Irusta

Research output: Contribution to journal › Article › peer-review

4 Citations (SciVal)

Abstract

The risk of clot formation in blood-contacting devices is a significant concern. Therefore, development of biomaterials with improved hemocompatibility is a clinical need. Altering surface properties is an effective strategy to enhance the hemocompatibility. We have investigated the effect of hydrophilic polyethylene glycol (PEG) amount over the hydrophobic polycarbonate (PC) on hemocompatibility of polyurethanes. The presence of PEG on the surface was evaluated using ATR, AFM, and WCA. At above 20% of PEG to PC ratios, exhibit zero WCA, considerable improvement in hemocompatibility, was achieved. The results indicated the synthesized PUs could be used as coatings of cardiovascular devices.

Original language	English
Pages (from-to)	531-539
Number of pages	9
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	71
Issue number	7
Early online date	16 Dec 2020
DOIs	https://doi.org/10.1080/00914037.2020.1857760
Publication status	Published - 31 Jan 2022

Bibliographical note

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

Hemocompatibility
hydrophilicity
PEG
polyurethane

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
Polymers and Plastics

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10.1080/00914037.2020.1857760

Cite this

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abstract = "The risk of clot formation in blood-contacting devices is a significant concern. Therefore, development of biomaterials with improved hemocompatibility is a clinical need. Altering surface properties is an effective strategy to enhance the hemocompatibility. We have investigated the effect of hydrophilic polyethylene glycol (PEG) amount over the hydrophobic polycarbonate (PC) on hemocompatibility of polyurethanes. The presence of PEG on the surface was evaluated using ATR, AFM, and WCA. At above 20\% of PEG to PC ratios, exhibit zero WCA, considerable improvement in hemocompatibility, was achieved. The results indicated the synthesized PUs could be used as coatings of cardiovascular devices.",

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T1 - Enhanced hemocompatibility of a PEGilated polycarbonate based segmented polyurethane

AU - Vakili, Helma

AU - Mohseni, Mohsen

AU - Ghanbari, Hossein

AU - Yahyaei, Hossein

AU - Makki, Hesam

AU - González, Alba

AU - Alonso-Varona, Ana

AU - Garrido Pascual, Patricia

AU - Irusta, Lourdes

PY - 2022/1/31

Y1 - 2022/1/31

N2 - The risk of clot formation in blood-contacting devices is a significant concern. Therefore, development of biomaterials with improved hemocompatibility is a clinical need. Altering surface properties is an effective strategy to enhance the hemocompatibility. We have investigated the effect of hydrophilic polyethylene glycol (PEG) amount over the hydrophobic polycarbonate (PC) on hemocompatibility of polyurethanes. The presence of PEG on the surface was evaluated using ATR, AFM, and WCA. At above 20% of PEG to PC ratios, exhibit zero WCA, considerable improvement in hemocompatibility, was achieved. The results indicated the synthesized PUs could be used as coatings of cardiovascular devices.

AB - The risk of clot formation in blood-contacting devices is a significant concern. Therefore, development of biomaterials with improved hemocompatibility is a clinical need. Altering surface properties is an effective strategy to enhance the hemocompatibility. We have investigated the effect of hydrophilic polyethylene glycol (PEG) amount over the hydrophobic polycarbonate (PC) on hemocompatibility of polyurethanes. The presence of PEG on the surface was evaluated using ATR, AFM, and WCA. At above 20% of PEG to PC ratios, exhibit zero WCA, considerable improvement in hemocompatibility, was achieved. The results indicated the synthesized PUs could be used as coatings of cardiovascular devices.

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KW - hydrophilicity

KW - PEG

KW - polyurethane

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DO - 10.1080/00914037.2020.1857760

M3 - Article

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Enhanced hemocompatibility of a PEGilated polycarbonate based segmented polyurethane

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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