Engineering of crystalline combination inhalation particles of a long-acting beta2-agonist and a corticosteroid

Chonladda Pitchayajittipong, Jagdeep Shur, Robert Price

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

PURPOSE: Engineering of inhalation particles incorporating, in each individual particle, a combination of a long-acting beta-agonist and a glucocorticosteroid in a pre-determined and constant ratio for delivery via a dry powder inhaler (DPI).

METHODS: Individual crystalline particles containing both the glucocorticosteroid fluticasone propionate (FP) and long-acting beta-agonist salmeterol (SX) were prepared, in a ratio of 10:1, using the solution atomization and crystallization by sonication (SAX) process. Combination drug particles were characterized by particle size, morphology, crystallinity and aerosolisation efficiency using inertial impaction.

RESULTS: Combination drug particles were spherical and crystalline, with a median diameter of 4.68 +/- 0.01 microm. Aerosolisation of formulations containing combination drug particles resulted in greater uniformity in delivery ratios of both actives across all stages of the impactor before and after storage.

CONCLUSIONS: Actives in a pre-determined dose ratio can be crystallised in a single particle using the SAX process.

Original languageEnglish
Pages (from-to)2657-2666
Number of pages10
JournalPharmaceutical Research
Volume26
Issue number12
Early online date25 Sep 2009
DOIs
Publication statusPublished - 1 Dec 2009

Keywords

  • Administration, Inhalation
  • Adrenal Cortex Hormones
  • Adrenergic beta-Agonists
  • Albuterol
  • Androstadienes
  • Bronchodilator Agents
  • Calorimetry, Differential Scanning
  • Drug Combinations
  • Drug Storage
  • Inhalation
  • Microscopy, Electron, Scanning
  • Particle Size
  • Powders
  • Protein Engineering

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