Engineering aspects of FlowNMR spectroscopy setups for online analysis of solution-phase processes

Asad Saib, Alejandro Bara-Estaún, Owen J. Harper, Daniel B.G. Berry, Isabel A. Thomlinson, Rachael Broomfield-Tagg, John P. Lowe, Catherine L. Lyall, Ulrich Hintermair

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)


Online analysis and monitoring of solution phase chemistry by way of nuclear magnetic resonance spectroscopy on a recirculating sample from an external reaction vessel (FlowNMR) has proven to be a valuable tool for understanding the dynamic behaviour of complex solution-phase systems in real time. A variety of flow cells and setups have been used at both low and high magnetic field strengths for various applications, and the choice of materials, dimensions and components can have a profound impact on the quality and relevance of the data obtained. Here we review some fundamental engineering aspects of FlowNMR setups to help avoid common pitfalls and work towards establishing good practice quality guidelines (GxP) for FlowNMR investigations in academia and industry. This journal is

Original languageEnglish
Pages (from-to)1548-1573
Number of pages26
JournalReaction Chemistry and Engineering
Issue number9
Early online date2 Aug 2021
Publication statusPublished - 24 Aug 2021

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (miscellaneous)
  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes


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