Endothelin neurotransmitter signalling controls zebrafish social behaviour

Hector Carreno-Gutierrez, Sarah Colanesi, Ben Cooper, Robert N. Kelsh, Florian Reichmann, Andrew Young, Will Norton

Research output: Contribution to journalArticle

Abstract

The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa −/− mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa −/− providing an insight into how the brain controls social interactions.
Original languageEnglish
Article number3040
JournalScientific Reports
Volume9
Issue number1
Early online date28 Feb 2019
DOIs
Publication statusE-pub ahead of print - 28 Feb 2019

ASJC Scopus subject areas

  • General

Cite this

Carreno-Gutierrez, H., Colanesi, S., Cooper, B., Kelsh, R. N., Reichmann, F., Young, A., & Norton, W. (2019). Endothelin neurotransmitter signalling controls zebrafish social behaviour. Scientific Reports, 9(1), [3040]. https://doi.org/10.1038/s41598-019-39907-7

Endothelin neurotransmitter signalling controls zebrafish social behaviour. / Carreno-Gutierrez, Hector; Colanesi, Sarah; Cooper, Ben; Kelsh, Robert N.; Reichmann, Florian; Young, Andrew ; Norton, Will.

In: Scientific Reports, Vol. 9, No. 1, 3040, 01.12.2019.

Research output: Contribution to journalArticle

Carreno-Gutierrez, H, Colanesi, S, Cooper, B, Kelsh, RN, Reichmann, F, Young, A & Norton, W 2019, 'Endothelin neurotransmitter signalling controls zebrafish social behaviour', Scientific Reports, vol. 9, no. 1, 3040. https://doi.org/10.1038/s41598-019-39907-7
Carreno-Gutierrez H, Colanesi S, Cooper B, Kelsh RN, Reichmann F, Young A et al. Endothelin neurotransmitter signalling controls zebrafish social behaviour. Scientific Reports. 2019 Dec 1;9(1). 3040. https://doi.org/10.1038/s41598-019-39907-7
Carreno-Gutierrez, Hector ; Colanesi, Sarah ; Cooper, Ben ; Kelsh, Robert N. ; Reichmann, Florian ; Young, Andrew ; Norton, Will. / Endothelin neurotransmitter signalling controls zebrafish social behaviour. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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