Endoscopic sensing of distal lung physiology

Debaditya Choudhury, Michael G. Tanner, Sarah McAughtrie, Fei Yu, Bethany Mills, Tushar R. Choudhary, Sohan Seth, Thomas H. Craven, James M. Stone, Ioulia K. Mati, Colin J. Campbell, Mark Bradley, Christopher K.I. Williams, Kevin Dhaliwal, Timothy A. Birks, Robert R. Thomson

Research output: Contribution to journalConference article

Abstract

The alveolar space forms the distal end of the respiratory tract where chemoreceptor driven gas exchange processes occur. In healthy humans, the physiological state within the alveoli is tightly regulated by normal homeostatic mechanisms. However, pulmonary abnormalities such as chronic obstructive pulmonary disease may induce significant perturbation of the homeostatic baselines of physiology as well as cause host tissue damage. Therefore, physiological parameters (pH, glucose, oxygen tension) within the alveolar space provide a key biomarker of innate defence. Here, we discuss an endoscope-deployable fibre-optic optrode for sensing pH in the alveolar space. In order to circumvent the unwanted Raman signal generated within the fibre, the optrode consists of a custom asymmetric dual-core optical fibre designed for spatially separated optical pump delivery and SERS signal collection. pH sensing is achieved using the surface enhanced Raman spectroscopy (SERS) signal generated from functionalised gold nanoshell sensors. We show a ∼ 100-fold increase in SERS signal-to-fibre background ratio and demonstrate multiple site pH sensing in the alveoli of an ex vivo ovine lung model with a measurement accuracy of ± 0.07 pH unit.

Original languageEnglish
Article number012009
JournalJournal of Physics: Conference Series
Volume1151
Issue number1
DOIs
Publication statusPublished - 18 Mar 2019
EventNewton Researcher Links Workshop 2018: Bio-Photonics For Medical Technologies - Malacca, Malaysia
Duration: 23 Jul 201825 Jul 2018

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Choudhury, D., Tanner, M. G., McAughtrie, S., Yu, F., Mills, B., Choudhary, T. R., ... Thomson, R. R. (2019). Endoscopic sensing of distal lung physiology. Journal of Physics: Conference Series, 1151(1), [012009]. https://doi.org/10.1088/1742-6596/1151/1/012009