Endoscopic sensing of alveolar pH

D. Choudhury, M. G. Tanner, S. McAughtrie, F. Yu, B. Mills, T. R. Choudhary, S. Seth, T. H. Craven, J. M. Stone, I. K. Mati, C. J. Campbell, M. Bradley, C. K. I. Williams, K. Dhaliwal, T. A. Birks, R. R. Thomson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-tofiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

LanguageEnglish
Article number274960
Pages243-259
Number of pages17
JournalBiomedical Optics Express
Volume8
Issue number1
DOIs
StatusPublished - 1 Jan 2017

Fingerprint

Raman Spectrum Analysis
Nanoshells
Raman spectroscopy
Optical Fibers
endoscopes
Endoscopes
ventilation
Gold
lungs
Ventilation
delivery
Sheep
optical fibers
pumps
gold
Lung
fibers
sensors

Keywords

  • Optical diagnostics for medicine
  • Spectroscopy, tissue diagnostics

Cite this

Choudhury, D., Tanner, M. G., McAughtrie, S., Yu, F., Mills, B., Choudhary, T. R., ... Thomson, R. R. (2017). Endoscopic sensing of alveolar pH. Biomedical Optics Express, 8(1), 243-259. [274960]. https://doi.org/10.1364/BOE.8.000243

Endoscopic sensing of alveolar pH. / Choudhury, D.; Tanner, M. G.; McAughtrie, S.; Yu, F.; Mills, B.; Choudhary, T. R.; Seth, S.; Craven, T. H.; Stone, J. M.; Mati, I. K.; Campbell, C. J.; Bradley, M.; Williams, C. K. I.; Dhaliwal, K.; Birks, T. A.; Thomson, R. R.

In: Biomedical Optics Express, Vol. 8, No. 1, 274960, 01.01.2017, p. 243-259.

Research output: Contribution to journalArticle

Choudhury, D, Tanner, MG, McAughtrie, S, Yu, F, Mills, B, Choudhary, TR, Seth, S, Craven, TH, Stone, JM, Mati, IK, Campbell, CJ, Bradley, M, Williams, CKI, Dhaliwal, K, Birks, TA & Thomson, RR 2017, 'Endoscopic sensing of alveolar pH', Biomedical Optics Express, vol. 8, no. 1, 274960, pp. 243-259. https://doi.org/10.1364/BOE.8.000243
Choudhury D, Tanner MG, McAughtrie S, Yu F, Mills B, Choudhary TR et al. Endoscopic sensing of alveolar pH. Biomedical Optics Express. 2017 Jan 1;8(1):243-259. 274960. https://doi.org/10.1364/BOE.8.000243
Choudhury, D. ; Tanner, M. G. ; McAughtrie, S. ; Yu, F. ; Mills, B. ; Choudhary, T. R. ; Seth, S. ; Craven, T. H. ; Stone, J. M. ; Mati, I. K. ; Campbell, C. J. ; Bradley, M. ; Williams, C. K. I. ; Dhaliwal, K. ; Birks, T. A. ; Thomson, R. R. / Endoscopic sensing of alveolar pH. In: Biomedical Optics Express. 2017 ; Vol. 8, No. 1. pp. 243-259.
@article{8dccfc0f28204915b4514b25cfd14e34,
title = "Endoscopic sensing of alveolar pH",
abstract = "Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-tofiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.",
keywords = "Optical diagnostics for medicine, Spectroscopy, tissue diagnostics",
author = "D. Choudhury and Tanner, {M. G.} and S. McAughtrie and F. Yu and B. Mills and Choudhary, {T. R.} and S. Seth and Craven, {T. H.} and Stone, {J. M.} and Mati, {I. K.} and Campbell, {C. J.} and M. Bradley and Williams, {C. K. I.} and K. Dhaliwal and Birks, {T. A.} and Thomson, {R. R.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1364/BOE.8.000243",
language = "English",
volume = "8",
pages = "243--259",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "1",

}

TY - JOUR

T1 - Endoscopic sensing of alveolar pH

AU - Choudhury, D.

AU - Tanner, M. G.

AU - McAughtrie, S.

AU - Yu, F.

AU - Mills, B.

AU - Choudhary, T. R.

AU - Seth, S.

AU - Craven, T. H.

AU - Stone, J. M.

AU - Mati, I. K.

AU - Campbell, C. J.

AU - Bradley, M.

AU - Williams, C. K. I.

AU - Dhaliwal, K.

AU - Birks, T. A.

AU - Thomson, R. R.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-tofiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

AB - Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-tofiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

KW - Optical diagnostics for medicine

KW - Spectroscopy, tissue diagnostics

UR - http://www.scopus.com/inward/record.url?scp=85008946323&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1364/BOE.8.000243

U2 - 10.1364/BOE.8.000243

DO - 10.1364/BOE.8.000243

M3 - Article

VL - 8

SP - 243

EP - 259

JO - Biomedical Optics Express

T2 - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 1

M1 - 274960

ER -