Enantioselective palladium catalysed allylic substitution with thienyl oxazoline ligands

C.G. Frost, Jonathan M J Williams

Research output: Contribution to journalArticle

Abstract

Homochiral thienyl oxazolines have been employed as ligands for enantioselective palladium catalysed allylic substitution. The ligands are straightforward to prepare in one step from commercially available materials and afford good levels of asymmetric induction in the catalytic allylic substitution process of up to 81% ee. The stereochemical outcome is described in terms of steric and electronic factors.
Original languageEnglish
Pages (from-to)2015-2018
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number12
DOIs
Publication statusPublished - 19 Mar 1993

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