Abstract
The first examples of enantioselective intermolecular [2+2] photocycloadditions of isoquinolone with alkenes are reported. Photoreactions were carried out at low temperature in the presence of a chiral hydrogen-bonding template, which effectively shields one face of the substrate through formation of a hydrogen-bonded supramolecular complex. Functionalized cyclobutane products were obtained in excellent yields (86–98%) and with outstanding regio-, diastereo-, and enantioselectivity (88–99% ee).
| Original language | English |
|---|---|
| Pages (from-to) | 14948-14951 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 135 |
| Issue number | 40 |
| Publication status | Published - 30 Sept 2013 |