Enantiomerism of medicinal products – a new paradigm in environmental risk assessment

Barbara Kasprzyk-Hordern, John Bagnall, David Baker, Sian Evans

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chiral pharmacologically active compounds (PACs) are
environmental pollutants. They enter the environment mainly through
insufficiently treated sewage, waste effluents from manufacturing
processes, runoff and sludge. They are bioactive, ubiquitous and
persistent with synergistic properties. Surprisingly, the environmental
fate and effects of PACs are assessed without taking into consideration
their enantiomeric forms (this is despite existing knowledge on
enantiomer dependant toxicity of PACs to humans, taking thalidomide
as a flagship example). Such an approach leads to an underestimation of
toxicity of PACs, incorrect environmental risk assessment, and direct
risk to the environment and human health, as PACs are likely to be
present in the environment in their non-racemic forms(in the case of
single enantiomer PACs racemisation in-vivo can also take place). This
presentation aims to discuss: The phenomenon of chirality in the context
of fate and effect of chiral pharmacologically active compounds (PACs)
in the environment Monitoring of several wastewater treatment plants
and receiving waters in the UK to study stereoselective biodegradation
of PACs Stereoselective biodegradation of PACs in river microcosms
Implications of enantiomer-dependant fate of PACs for prodecures
applied in environmental risk assessment
Original languageEnglish
Title of host publicationBook of abstracts, 23rd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe)
Publication statusPublished - 2013
Event23rd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe) - Glasgow, UK United Kingdom
Duration: 12 May 201316 May 2013

Conference

Conference23rd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe)
CountryUK United Kingdom
CityGlasgow
Period12/05/1316/05/13

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Kasprzyk-Hordern, B., Bagnall, J., Baker, D., & Evans, S. (2013). Enantiomerism of medicinal products – a new paradigm in environmental risk assessment. In Book of abstracts, 23rd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe)